200801-95-2Relevant academic research and scientific papers
SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY
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Page/Page column 43, (2010/02/11)
Compounds represented by formula I: I are disclosed. AR represents an aromatic group containing 6-10 atoms; and represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase
Liverton, Nigel J.,Butcher, John W.,Claiborne, Christopher F.,Claremon, David A.,Libby, Brian E.,Nguyen, Kevin T.,Pitzenberger, Steven M.,Selnick, Harold G.,Smith, Garry R.,Tebben, Andrew,Vacca, Joseph P.,Varga, Sandor L.,Agarwal, Lily,Dancheck, Kim,Forsyth, Amy J.,Fletcher, Daniel S.,Frantz, Betsy,Hanlon, William A.,Harper, Coral F.,Hofsess, Scott J.,Kostura, Matthew,Lin, Jiunn,Luell, Sylvie,O'Neill, Edward A.,Orevillo, Chad J.,Pang, Margaret,Parsons, Janey,Rolando, Anna,Sahly, Yousif,Visco, Denise M.,O'Keefe, Stephen J.
, p. 2180 - 2190 (2007/10/03)
Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays of tumor necrosis factor-α (TNF-α) release and an animal model of rheumatoid arthritis. The SAR
Substituted imidazoles having cytokine inhibitory activity
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, (2008/06/13)
Compounds represented by formula I: STR1 are disclosed. AR represents an aromatic group containing 6-10 atoms; and STR2 represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additio
