74783-55-4

Upstream product

• 81029-03-0 4-Methoxy-2,3-dimethylnitrobenzene 
• 108-24-7 acetic anhydride 
• 526-75-0 2,3-Dimethylphenol 
• 2011-57-6 N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide 
• 74-88-4 methyl iodide 
• 74783-54-3 1-hydroxy-2,3-dimethyl-4-nitrosobenzene 
• 3096-69-3 4-amino-2,3-dimethylphenol 

Downstream Products

• 179067-16-4 4-methoxy-2,3-dimethylaniline hydrochloride 

Relevant academic research and scientific papers

Synthesis of 4-deoxycarbazomycin B: A convenient alternative

4-Deoxycarbazomycin B(3) was synthesized by condensation of 4-methoxy-2,3-dimethylacetanilide (8) with bromobenzene in presence of cuprous iodide and potassium carbonate, and subsequent hydrolysis with 20% aqueous ethanolic KOH, followed by cyclisation of the resulting substituted diphenylamine (9) with palladium acetate in acetic acid.

A new synthesis of 4-deoxycarbazomycin B and its antimicrobial properties

A new synthesis 4-deoxycarbazomycin B (3) has ben achieved using Japp-Klingemann reaction for the preparation of the required hydrazone 12 starting from the amine hydrochloride 9 and 2-hydroxymethylenecyclohexanone 11. The hydrazone 12 on indolisation with cone. HCl and AcOH furnishes the keto-tetrahydrocarbazole 13 which on Wolff-Kishner reduction followed by dehydrogenation with Pd/C affords 3. A new method for the synthesis of the starting amine hydrochloride 9 has been developed. Compound 3 shows significant inhibitory activity against various gram-positive and gram-negative bacteria.