201289-18-1Relevant academic research and scientific papers
Facile and mild synthesis of linear and cyclic peptides via thioesters
Agrigento, Paola,Albericio, Fernando,Chamoin, Sylvie,Dacquignies, Isabelle,Koc, Halil,Eberle, Martin
supporting information, p. 3922 - 3925 (2014/08/18)
Thioester-mediated peptide bond formation has recently garnered a lot of attention, most notably in its relevance to condensation of large peptide fragments. Herein, a simple and general ligation method for the preparation of linear and cyclic peptides, starting from peptide thioester, mainly p-chlorophenyl, precursors is reported. The inherent advantages of this method are the low epimerization, reduced dimerization, use of mild reaction conditions, and elimination of superfluous coupling reagents.
