201294-65-7Relevant academic research and scientific papers
Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines
Bisset, Alexander A.,Dishington, Allan,Jones, Teyrnon,Clarkson, Guy J.,Wills, Martin
, p. 7207 - 7220 (2017/09/12)
The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.
Aspects of the chemistry of dioxolanes: Synthesis of C-nucleoside analogues
Mellor, Ben J.,Murray, Patricia E.,Thomas, Eric J.
, p. 243 - 256 (2007/10/03)
Chiral 2-formyl and 2-(1-oxoalkyl)-1,3-dioxolanes have been prepared by ozonolysis of the corresponding alkenes and by oxidation of 2-(1-hydroxyalkyl)-1,3-dioxolanes, which are readily available from 2-(tributylstannyl)dioxolanes, and taken through to αβ-unsaturated esters by condensation with stabilized ylids. The (4'S,5'S)-1-benzyl-5-[4,5-bis(ethoxycarbonyl)-1,3-dioxolan-2-yl]-2-pyridone 47 was prepared as an anologue of a C-nucleoside, but was found to be unstable.
