2015-57-8

Usage

Uses

Used in Perfumery Industry:
Cyclopentanol, 1-(phenylmethyl)is used as a fragrance ingredient for its strong, floral scent, adding depth and complexity to perfume compositions.
Used in Flavor Industry:
In the flavor industry, Cyclopentanol, 1-(phenylmethyl)serves as a flavoring agent, enhancing the taste profiles of various food and beverage products by imparting unique, floral notes.
Used in Pharmaceutical Industry:
Cyclopentanol, 1-(phenylmethyl)is utilized as a solvent or intermediate in the synthesis of active pharmaceutical ingredients, contributing to the development of new medications and drug formulations.
Used in Consumer Product Industry:
Cyclopentanol, 1-(phenylmethyl)is employed in the production of various consumer products, such as cosmetics and personal care items, due to its versatile properties as a fragrance and flavoring agent, as well as its solvent capabilities.

Upstream product

• 120-92-3 cyclopentanone 
• 6921-34-2 benzylmagnesium chloride 
• 4410-78-0 (cyclopentylmethyl)benzene 
• 100-39-0 benzyl bromide 
• 5281-18-5 benzaldehyde, hydrazone 
• 100-52-7 benzaldehyde 
• 52939-60-3 4-benzyl-1,6-heptadien-4-ol 
• 101-41-7 benzeneacetic acid methyl ester 
• 13802-21-6 1-Benzyl-cyclopentyl-hydroperoxide 

Downstream Products

• 4410-77-9 benzylidenecyclopentane 
• 15507-35-4 1-benzylcyclopentene 
• 40399-86-8 N-(1-benzyl-cyclopentyl)-benzamide 
• 39162-09-9 [2-(1-Benzyl-cyclopentyloxy)-ethyl]-diethyl-amine 
• 39162-10-2 [2-(1-Benzyl-cyclopentyloxy)-ethyl]-diisopropyl-amine 
• 568591-02-6 (S)-2-(1-Benzyl-cyclopentyloxycarbonylamino)-hexanoic acid methyl ester 
• 10487-96-4 1-phenylcyclopentanol 
• 1604-02-0 1-propylcyclopentanol 
• 1462-96-0 1-ethylcyclopentanol 
• 36399-21-0 1-allylcyclopentan-1-ol 
• 2867-63-2 2-benzylcyclopentanone 
• 68975-22-4 (R)-3-benzyltetrahydro-2H-pyran-2-one 
• 1401512-33-1 N-(1-benzylcyclopentyl)-4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 
• 19165-95-8 1-benzylcyclopentylamine 

Relevant academic research and scientific papers

Samarium-based Grignard-type addition of organohalides to carbonyl compounds under catalysis of CuI

Grignard-type additions were readily achieved under the mediation of CuI (10 mol%) and samarium (2 equiv.) by employing various organohalides,e.g.benzyl, aryl, heterocyclic and aliphatic halides (Cl, Br or I), and diverse carbonyl compounds (e.g.carbonic esters, carboxylic esters, acid anhydrides, acyl chlorides, ketones, aldehydes, propylene epoxides and formamides) to afford alcohols, ketones and aldehydes, respectively, with high efficiency and chemoselectivity, in which the organosamarium intermediate might be involved.

A Selective and Functional Group-Tolerant Ruthenium-Catalyzed Olefin Metathesis/Transfer Hydrogenation Tandem Sequence Using Formic Acid as Hydrogen Source

A ruthenium-catalyzed transfer hydrogenation of olefins utilizing formic acid as a hydrogen donor is described. The application of commercially available alkylidene ruthenium complexes opens access to attractive C(sp3)-C(sp3) bond formation in an olefin metathesis/transfer hydrogenation sequence under tandem catalysis conditions. High chemoselectivity of the developed methodology provides a remarkable synthetic tool for the reduction of various functionalized alkenes under mild reaction conditions. The developed methodology is applied for the formal synthesis of the drugs pentoxyverine and bencyclane.

Iron-Catalyzed Nucleophilic Addition Reaction of Organic Carbanion Equivalents via Hydrazones

Earth-abundant and well-defined iron complexes are found to be cheap and effective catalysts for a series of "umpolung" nucleophilic additions of hydrazones. The new catalytic system not only maintains the broad substrate scope of an earlier expensive ruthenium system but also attains chemoselectivity of different kinds of carbonyl groups. Furthermore, the iron catalyst enables this reaction at ambient temperature.

Regio- and enantioselective Baeyer-Villiger oxidation: Kinetic resolution of racemic 2-substituted cyclopentanones

A kinetic resolution of racemic 2-substituted cyclopentanones via highly regio- and enantioselective Baeyer-Villiger oxidation has been successfully developed. The reaction could afford the normal 6-substituted δ-lactones in up to 98% ee and >19/1 regioselectivity. Meanwhile, the unreacted ketones were recovered in excellent ee values (up to 98%). It represents the best results of the kinetic resolution of racemic 2-substituted cyclopentanones via nonenzymic asymmetric BV oxidation.

Photolysis of 1-alkylcycloalkanols in the presence of (diacetoxyiodo) benzene and I2. Intramolecular selectivity in the β-scission reactions of the intermediate 1-alkylcycloalkoxyl radicals

The C-C β-scission reactions of 1-alkylcycloalkoxyl radicals, generated photochemically by visible light irradiation of CH2Cl 2 solutions containing the parent 1-alkylcycloalkanols, (diacetoxy)-iodobenzene (DIB), and I2, have been investigated through the analysis of the reaction products. The 1-alkylcycloalkoxyl radicals undergo competition between ring opening and C-alkyl bond cleavage as a function of ring size and of the nature of the alkyl substituent. With the 1-propylcycloheptoxyl, 1-propylcyclooctoxyl, and 1-phenylcyclooctoxyl radicals, formation of products deriving from an intramolecular 1,5-hydrogen atom abstraction reaction from the cycloalkane ring has also been observed. The results are discussed in terms of release of ring strain associated to ring opening, stability of the alkyl radical formed by C-alkyl cleavage, and with cycloheptoxyl and cyclooctoxyl radicals, also in terms of the possibility of achieving a favorable geometry for intramolecular hydrogen atom abstraction.