201813-47-0

Upstream product

• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 768-60-5 4-methoxyphenylacetylen 
• 157869-15-3 2-((4-methoxyphenyl)ethynyl)aniline 
• 407-25-0 trifluoroacetic anhydride 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 5034-76-4 indoxole 
• 5782-11-6 2-(4-methoxyphenyl)-3-phenyl-1H-indole 
• 1233533-73-7 4-(2-(4-methoxyphenyl)-1H-indol-3-yl)benzonitrile 
• 1233533-72-6 2-(4-methoxyphenyl)-3-(p-tolyl)-1H-indole 
• 1286170-00-0 C₂₀H₁₆F₃NO₂ 

Relevant academic research and scientific papers

Palladium-catalyzed: C -glycosylation and annulation of o -alkynylanilines with 1-iodoglycals: Convenient access to 3-indolyl- C -glycosides

An efficient and practical approach for the synthesis of 3-indolyl-C-Δ1,2-glycosides through a palladium-catalyzed annulation/C-glycosylation sequence of o-alkynylanilines with 1-iodoglycals has been developed. This methodology has a wide scope of substra

Synthesis of 2,3-disubstituted indoles from alkynylanilines and 2-chlorophenols using palladium–dihydroxyterphenylphosphine catalyst

2,3-Disubstituted indoles bearing 2-hydroxyphenyl moieties at their C3 positions were synthesized from readily available 2-chlorophenols and alkynylanilines via aminopalladation/reductive elimination using Pd–dihydroxyterphenylphosphine catalyst. The catalyst accelerates the introduction of the 2-hydroxyphenyl group at the C3 position of the indole.

Copper-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o -alkynylphenols and anilines

The CuX (X = I, Br, Cl, CN)-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenol and -aniline derivatives give rise to 3-halo- and 3-cyanofuro[3,2-b]pyrroles, 3-iodo-, 3-bromo-, and 3-cyanobenzofurans, and 3-cyanoindoles, respectively.

2-Aryl and 2-Heteroaryl Indoles from 1-Alkynes and o- lodotrifluoroacetanilide through a Domino Copper-Catalyzed Coupling-Cyclization Process

(Matrix presented) A general method for the synthesis of 2-aryl and 2-heteroaryl indoles from aryl iodides and 1-alkynes through a domino copper-catalyzed process is reported. The best results have been obtained with [Cu(phen)(PPh3)2]NO3 in the presence of K 3PO4 in toluene or dioxane at 110°C. 2-Aryl and 2-heteroaryl indoles can also be isolated in good yields by using catalysts derived from Cul and PPh3 in dioxane at 110°C.