454713-45-2

Basic information

• Product Name: N-Boc-2-naphthylamine
• Synonyms: N-Boc-2-naphthylamine;N-2-NaphthalenylcarbaMic Acid 1,1-DiMethylethyl Ester
• CAS NO: 454713-45-2
• Molecular Formula: C₁₅H₁₇NO₂
• Molecular Weight: 243.30098
• Product Categories: Amines;Aromatics
• Mol File: 454713-45-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 335.5±11.0 °C(Predicted)
• Appearance: /
• Density: 1.144±0.06 g/cm3(Predicted)
• PKA: 13.86±0.30(Predicted)
• CAS DataBase Reference: N-Boc-2-naphthylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-2-naphthylamine(454713-45-2)
• EPA Substance Registry System: N-Boc-2-naphthylamine(454713-45-2)

Safety Data

• Hazardous Substances Data: 454713-45-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 454713-45-2 differently. You can refer to the following data:
1. N-Boc-2-naphthylamine can be used for the synthesis of biphenyl-carbamate, the most active analog of Rhazinilam, an antitumor agent
2. Used for the synthesis of biphenyl-carbamate, the most active analog of Rhazinilam, an antitumor agent.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 91-59-8 naphthalen-2-ylamine 
• 75-65-0 tert-butyl alcohol 
• 93-09-4 naphthalene-2-carboxylate 
• 454713-47-4 tert-butyl (1-bromonaphthalen-2-yl)carbamate 
• 108-24-7 acetic anhydride 
• 79-30-1 isobutyryl chloride 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 612-52-2 2-naphthylamine hydrochloride 
• 116632-14-5 2-amino-3-iodonaphthalene 
• 90016-93-6 2-Amino-1-iodonaphthalene 
• 454713-41-8 tert-butyl 1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 20191-75-7 1-bromo-2-naphthylamine 
• 17931-24-7 naphtho[2,1-d]thiazol-2(3H)-one 
• 7066-24-2 4H-benzo[f]quinazoline-1,3-dione 
• 7066-19-5 benzo[f]quinazolin-1(2H)-one 
• 73190-70-2 N-(naphthalen-2-yl)-2-phenylacetamide 
• 91-20-3 naphthalene 
• 1190098-20-4 1-(4-(methylsulfonyl)benzyl)-N-(naphthalen-2-yl)-1H-indazole-3-carboxamide 
• 454713-47-4 tert-butyl (1-bromonaphthalen-2-yl)carbamate 

Relevant articles and documents

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Synthesis of acylnaphthylamines and their applications in the formation of benzoquinazolines

The synthesis of acyl N-Boc-1- And N-Boc-2-naphthylamines and their transformation into alkyl substituted benzoquinazolines and benzoquinazolinones through the reaction with formamide or potassium cyanate in the presence of ammonium acetate is described.