581-97-5

Basic information

• Product Name: B-ACETAMIDONAPHTHALENE
• Synonyms: 2-acetamidonaphthalene;Acetamide,N-2-naphthalenyl-;Acetamide,N-2-naphthyl-;beta-acetamidonaphthalide;n-2-naphthalenyl-acetamid;n-2-naphthalenylacetamide;n-2-naphthyl-acetamid;N-Acetyl-β-naphthylamine
• CAS NO: 581-97-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22184
• EINECS: 209-476-6
• Product Categories: Aromatics, Intermediates, Miscellaneous Reagents
• Mol File: 581-97-5.mol
• Article Data: 82

Chemical Properties

• Melting Point: 240-241 °C
• Boiling Point: 413.6°Cat760mmHg
• Flash Point: 245.6°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 2.78E-07mmHg at 25°C
• Refractive Index: 1.648
• PKA: 15.12±0.30(Predicted)
• CAS DataBase Reference: B-ACETAMIDONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: B-ACETAMIDONAPHTHALENE(581-97-5)
• EPA Substance Registry System: B-ACETAMIDONAPHTHALENE(581-97-5)

Safety Data

• Hazardous Substances Data: 581-97-5(Hazardous Substances Data)

Usage

Chemical Properties

B-ACETAMIDONAPHTHALENE is Off-White Solid

Uses

B-ACETAMIDONAPHTHALENE was used in the preparation of novel phenyl pyrazolone-substituted 1H-benzo[g]pyrazolo[3,4-b]quinoline-3-ylamine derivatives that exhibits antituberculosis and antibacterial activities.

InChI:InChI=1/C12H11NO/c13-12(14)8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7H,8H2,(H2,13,14)

Upstream product

• 108-24-7 acetic anhydride 
• 91-59-8 naphthalen-2-ylamine 
• 71-43-2 benzene 
• 463-51-4 Ketene 
• 507-09-5 thioacetic acid 
• 625-77-4 N-acetylacetamide 
• 631-61-8 ammonium acetate 
• 135-19-3 β-naphthol 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 99988-93-9 thioacetic acid 2-naphthylamide 
• 100-47-0 benzonitrile 
• 10026-13-8 phosphorus pentachloride 
• 100485-52-7 2-acetonaphthone oxime 

Downstream Products

• 7597-73-1 N-(1-bromonaphthalen-2-yl)acetamide 
• 582-19-4 (3-fluoro-phenyl)-[2]naphthyl-amine 
• 111033-94-4 N-[2]naphthyl-acetamide; compound with 2.4.6-trinitro-toluene 
• 606-57-5 1-nitro-2-naphthylamine 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 86-60-2 7-aminonaphthalene-1-sulfonic acid 
• 81-05-0 6-aminonaphthalene-1-sulfonic acid 
• 861057-12-7 N-(1,6-dinitro-[2]naphthyl)-acetamide 
• 64574-27-2 N-(1,8-dinitro-[2]naphthyl)-acetamide 
• 3230-35-1 6-nitro-2-naphthylamine 
• 102877-11-2 2-Acetamido-6-nitro-naphthalin 
• 5419-82-9 1-nitro-2-acetylaminonaphthalene 
• 102877-13-4 N-(8-nitro-[2]naphthyl)-acetamide 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Dehydrative Beckmann rearrangement and the following cascade reactions

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.