20191-76-8

Basic information

• Product Name: 1-Amino-2,4-dibromonaphthalene
• Synonyms: 1-Amino-2,4-dibromonaphthalene;2,4-Dibromo-1-naphthalenamine;2,4-Dibromo-1-naphtylamine;2,4-Dibromonaphthalene-1-amine;2,4-dibromonaphthalen-1-amine
• CAS NO: 20191-76-8
• Molecular Formula: C₁₀H₇Br₂N
• Molecular Weight: 300.99
• Mol File: 20191-76-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 369.7°C at 760 mmHg
• Flash Point: 177.4°C
• Appearance: /
• Density: 1.902g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.738
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.22±0.10(Predicted)
• CAS DataBase Reference: 1-Amino-2,4-dibromonaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-2,4-dibromonaphthalene(20191-76-8)
• EPA Substance Registry System: 1-Amino-2,4-dibromonaphthalene(20191-76-8)

Safety Data

• Hazardous Substances Data: 20191-76-8(Hazardous Substances Data)

Usage

Uses

2,4-Dibromonaphthalen-1-amine is used as a reactant in the preparation of pyrazoles as inhibitors of macrophage migration inhibitory factor.

InChI:InChI=1/C10H7Br2N/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5H,13H2

Upstream product

• 134-32-7 1-amino-naphthalene 
• 86-57-7 1-Nitronaphthalene 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 130-13-2 sodium 4-amino-1-naphthalenesulfonate 
• 110-86-1 pyridine 
• 67-66-3 chloroform 
• 890-51-7 N-benzylidenenaphthalen-1-amine 
• 32666-56-1 1-amino-5,8-dihydronaphthalene 
• 7647-01-0 hydrogenchloride 
• 57045-94-0 N-(2,4-dibromo-[1]naphthyl)-acetamide 
• 84-86-6 4-amino-1-naphthalenesufonic acid 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 
• 1178865-89-8 2,4-bis(3,4-dimethoxyphenyl)naphthalen-1-amine 
• 1178865-90-1 2,4-bis(3,4,5-trimethylphenyl)naphthalen-1-amine 
• 2158303-49-0 1-bromo-3-(methoxymethoxy)naphthalene 
• 881811-70-7 2,4-diphenyl-1-naphthylamine 
• 881811-91-2 2,4-bis(4-trifluoromethylphenyl)-1-naphthylamine 
• 134-32-7 1-amino-naphthalene 
• 172943-00-9 5-bromonaphtho[1,2-d][1,2,3]oxadiazole 
• 94163-51-6 3-nitro-benzenesulfonic acid-(2,4-dibromo-[1]naphthylamide) 
• 52358-73-3 1,3-dibromonaphthalene 
• 2043962-01-0 4-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)naphthalen-2-ol 
• 2374831-10-2 ethyl 3-(3-methoxy-1-naphthylamino)benzoate 

Relevant articles and documents

Mild and Selective Method of Bromination of Flavonoids

A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.

Kras-G12C inhibitor heterocyclic compounds

The invention relates to Kras-G12C inhibitor heterocyclic compounds represented by formula I, a preparation method thereof, and application of the Kras-G12C inhibitor heterocyclic compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds of the general formula I are obtained through a series of reactions such as SN2 reaction, protection, coupling reaction, deprotection, condensation reaction and the like.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.