20193-67-3

Usage

Uses

Used in Chemical Synthesis:
2,2,2-Trifluoroethyl trifluoromethyl ether is used as a chemical intermediate for the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique properties contribute to the development of new compounds with specific applications in these industries.
Used in Solvent Applications:
2,2,2-TRIFLUOROETHYL TRIFLUOROMETHYL ETHER is utilized as a solvent in various industrial processes due to its ability to dissolve a wide range of substances. Its volatility and high boiling point make it an effective solvent for different chemical reactions and processes.
Used in Refrigeration Industry:
2,2,2-Trifluoroethyl trifluoromethyl ether is used as a refrigerant in the refrigeration industry. Its high boiling point and low surface tension contribute to its effectiveness in cooling systems, providing efficient heat transfer and maintaining desired temperatures.
Used in Aerosol Propellants:
In the production of aerosol propellants, 2,2,2-trifluoroethyl trifluoromethyl ether is used as a propellant. Its volatility allows it to create the pressure needed to dispense the contents of aerosol cans, making it suitable for various consumer and industrial products.
Used in Environmental Management:
Although 2,2,2-trifluoroethyl trifluoromethyl ether is a potential environmental pollutant, it is also used in the development of strategies for its proper management and disposal. This includes finding ways to minimize its release into the environment and mitigate its adverse effects on the ecosystem.

InChI:InChI=1/C3H2F6O/c4-2(5,6)1-10-3(7,8)9/h1H2

Upstream product

• 373-91-1 hypofluorous acid trifluoromethyl ester 
• 75-38-7 Vinylidene fluoride 
• 84011-15-4 1,1-difluoro-2-(trifluoromethoxy)ethane 
• 598-88-9 1,2-dichloro-1,2-difluoroethene 
• 56-23-5 tetrachloromethane 
• 75-89-8 2,2,2-trifluoroethanol 
• 1645-80-3 2,2-Difluor-2-chlor-1-trifluormethoxy-aethan 
• 112915-23-8 2,2,2-Trifluoroethyl Fluoroformate 

Downstream Products

• 142469-08-7 1,1,1,2,2,3,3-heptafluoro-3-(2,2,2-trifluoroethoxy)propane 

Relevant academic research and scientific papers

Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods

Synthetic methods, especially those that use bromine trifluoride as a fluorinating agent, are described for the preparation of a number of fluorinated ethyl methyl ethers in good yield and high purity. In all cases, medium-scale syntheses (8-22g) of potentially anesthetic compounds have been accomplished. The compounds are of sufficient purity (>99%) for biological evaluation.

Direct Trifluoromethylation of Alcohols Using a Hypervalent Iodosulfoximine Reagent

The direct trifluoromethylation of a variety of aliphatic alcohols using a hypervalent iodosulfoximine reagent afforded the corresponding ethers in moderate to good yields (14–72 %). Primary, secondary, and even tertiary alcohols, including examples derived from natural products, underwent this transformation in the presence of catalytic amounts of zinc bis(triflimide). Typical reaction conditions involved a neat mixture of 6.0 equivalents of the alcohol with 1.0 equivalent of the reagent, with the majority of reactions complete within 2 h with 2.5 mol % of the Lewis acid catalyst. Furthermore, experimental evidence was provided that the C?O bond-forming process occurred via the coordination of the alcohol to the iodine atom and subsequent reductive elimination.

Compositions of a hydrofluoroether and a hydrofluorocarbon

This invention relates to compositions that include at least one fluoroether and at least one hydrofluorocarbon. Included in this invention are compositions of a cyclic or acyclic hydrofluoroether of the formula CaFbH2a+2?bOc wherein a=2 or 3 and 3≦b≦8 and c=1 or 2 and a hydrofluorocarbon of the formula CnFmH2n+2?m wherein 1≦n≦4 and 1≦m≦8. Such compositions may be used as refrigerants, cleaning agents, expansion agents for polyolefins and polyurethanes, aerosol propellants, heat transfer media, gaseous dielectrics, fire extinguishing agents, power cycle working fluids, polymerization media, particulate removal fluids, carrier fluids, buffing abrasive agents, and displacement drying agents.

Polyfluorinated carbocations stabilized by oxygen and sulfur

Polyfluorinated oxonium cations RfCH2OCFX(+) and acyclic perfluorinated sulfonium cations RfSCF2(+) are prepared by the reaction of corresponding ethers or sulfides with antimony pentafluoride in SO2ClF solvent and characterized by 19F and 1H spectroscopy. Based on experimental data the relative stability of polyfluorinated oxonium cations are determined.

Relative Rate Constants for the Reactions of CF3OF with Olefins in Solution

The addition reactions of CF3OF to chloro fluoro olefins have been studied in solution at low temperature (-78, -105 deg C), and their relative rate constants have been determined using the kinetic approach of competition reactions.The reactivity and regio- and stereoselectivity are consistent with a free radical chain-propagating reaction in which the alkenes are attacked by the CF3O* radical generated by homolytic cleavage of the O-F bond in the CF3OF molecule.

Synthesis of Perfluoroethylmethylether by Direct Fluorination

The direct fluorination of trifluoromethylethers prepared from ethylene or fluorinated ethylenes with trifluoromethyl hypofluorite proceeded in excellent yield to obtain perfluoroethylmethylethers.

Comparison of the Reactivity of CF3OX (X = Cl, F) with Some Simple Alkenes

Reactions of CF3OX (X = Cl, F) with a variety of simple alkenes were carried out to compare the regio- and stereoselectivity of the additions to carbon-carbon double bonds.The observed addition products with CF3OCl are consistent with an electrophilic syn addition.With CF3OF the observed products indicate a different regioselectivity and low stereoselectivity, consistent with a free-radical addition.