201996-23-8

Basic information

• Product Name: Benzenemethanol, 2-hydroxy-a-(trifluoromethyl)-
• Synonyms: 2-(2,2,2-Trifluoro-1-hydroxy-ethyl)-phenol;2-(2,2,2-trifluoro-1-hydroxyethyl)phenol;2-hydroxy-1-phenyl-trifluoromethylcarbinol;2-(1-hydroxy-2,2,2-trifluoroethyl)phenol
• CAS NO: 201996-23-8
• Molecular Formula: C8H7F3O2
• Molecular Weight: 192.138
• Mol File: 201996-23-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-hydroxy-a-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-hydroxy-a-(trifluoromethyl)-(201996-23-8)
• EPA Substance Registry System: Benzenemethanol, 2-hydroxy-a-(trifluoromethyl)-(201996-23-8)

Safety Data

• Hazardous Substances Data: 201996-23-8(Hazardous Substances Data)

Usage

Compound Type

Phenolic compound

Functional Groups

Trifluoromethyl group attached to the benzene ring, hydroxy group at the para position

Applications

Used in pharmaceutical and agrochemical industries, as an intermediate in organic synthesis, building block for specialty chemicals, reagent in organic synthesis

Safety Information

Considered hazardous, handle and store with proper safety precautions

Upstream product

• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 108-95-2 phenol 
• 33953-86-5 trifluoroacetaldehyde hydrate 
• 55605-84-0 trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal 
• 135-02-4 ortho-anisaldehyde 
• 26902-84-1 2,2,2-trifluoro-1-(2-methoxyphenyl)ethanol 

Downstream Products

• 440659-12-1 2-(2,2,2-trifluoroethyl)phenol 
• 440659-03-0 2-(1-chloro-2,2,2-trifluoroethyl)phenol 

Relevant articles and documents

Electrochemical oxidation of 2,2,2-trifluoroethanol to trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal

Electrochemical oxidation of 2,2,2-trifluoroethanol (1) gave trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal (2b), which was more reactive than commercially available trifluoroacetaldehyde ethyl hemi-acetal (2a). The high reactivity of 2b was utiliz

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).