202390-91-8

Upstream product

• 202390-90-7 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester 
• 72594-56-0 2-(2-Iodo-5-methoxy-phenyl)-ethanol 
• 72594-60-6 1-Iodo-2-(2-iodo-ethyl)-4-methoxy-benzene 
• 75534-35-9 2-(2-bromo-5-methoxyphenyl)ethan-1-ol 
• 139469-06-0 1-bromo-5-dimethoxy-2-vinylbenzene 
• 225526-36-3 2-(2-(2-Bromo-5-methoxyphenyl)ethoxy)tetrahydropyran 

Relevant academic research and scientific papers

Synthesis of a phenolic analog of aphidicolin. Diminished stereoselection in intramolecular 6-exo Heck reactions of substrates having a hydrocarbon tether

Spirotetracycle 14, generated by intramolecular Heck cyclization of 13, was converted to the phenolic analog 20 of aphidicolin. That the nature of the tether connecting insertion partners can dramatically alter diastereoselection in intramolecular Heck reactions is also demonstrated.