225526-36-3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 75534-35-9 2-(2-bromo-5-methoxyphenyl)ethan-1-ol 
• 139469-06-0 1-bromo-5-dimethoxy-2-vinylbenzene 

Downstream Products

• 72594-56-0 2-(2-Iodo-5-methoxy-phenyl)-ethanol 
• 72594-60-6 1-Iodo-2-(2-iodo-ethyl)-4-methoxy-benzene 
• 202390-91-8 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butan-1-ol 
• 202390-90-7 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists

This invention provides a compound of the formula: and its pharmaceutically acceptable salts, wherein R1 is C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl, halo C1-C6 alkyl or phenyl; R3 is hydrogen or halo; R4 and R5 are independently hydrogen, C1-C6 alkyl or halo C1-C6 alkyl; and n is one, two or three. These compounds are useful as analgesics or anti-inflammatory agents, or in the treatment of cardiovascular diseases, allergic disorders, angiogenesis, CNS disorders, emesis, gastrointestinal disorders, sunburn, urinary incontinence, or diseases, disorders or adverse conditions caused by Helicobacter pylori, or the like, in a mammalian subject, especially humans. Intermediates for preparation of the compounds of Formula (I) are also disclosed.

1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives

This invention relates to novel 1-trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives of the formula wherein R1is C1-C6alkyl; R2is hydrogen, C1-C6alkyl, halo C1

Synthesis of a phenolic analog of aphidicolin. Diminished stereoselection in intramolecular 6-exo Heck reactions of substrates having a hydrocarbon tether

Spirotetracycle 14, generated by intramolecular Heck cyclization of 13, was converted to the phenolic analog 20 of aphidicolin. That the nature of the tether connecting insertion partners can dramatically alter diastereoselection in intramolecular Heck reactions is also demonstrated.