20248-86-6Relevant academic research and scientific papers
Synthesis of Polycyclic Hexapeptides Containing Multiple Intramolecular Cross-Links
Bailey, Patrick D.,Carter, Steven R.,Clarke, David G. W.,Crofts, Gavin A.,Smith, Paul W.,Ward, Peter
, p. 3215 - 3218 (1992)
Two polycyclic peptides have been prepared in which all four of the ε-nitrogens of cyclo-(Lys-Lys-Gly)2 are interconnected by intra-molecular cross-links.One of these compounds possessed (CH2)6 units between the adjacent lysyl residues and 4,4'-dimethylenebiphenyl units between the skipped lysyl residues, whilst the other contained p-xylyl units between all four of the lysyl residues.
A novel naphthyridine tetramer that recognizes tandem G-G mismatches by the formation of an interhelical complex
Lu, Yihuan,Dohno, Chikara,Nakatani, Kazuhiko
, p. 754 - 757 (2020)
We have designed and synthesized a novel naphthyridine tetramer, p-NCTB, for the recognition of tandem guanine-guanine (G-G) mismatches in DNA. p-NCTB possesses a p-biphenyl linker connecting two naphthyridine carbamate dimer (NCD) moieties that recognize G-G mismatches. p-NCTB preferentially bound to tandem G-G mismatches in dCGGG/dCGGG over dCGG/dCGG. Two dCGGG/dCGGG sites were simultaneously recognized and were noncovalently cross-linked via the formation of inter- and intrastrand complexes with p-NCTB. The intrastrand binding was more favorable, which could allow p-NCTB to bind selectively to a sequence containing multiple dCGGG/dCGGG sites.
Synthesis and characterization of Manganese(II), Cobalt(II) and Copper(II) coordination polymers with a flexible zwitterionic based ligand
?ift?i, Esengül,Ar?c?, Mürsel,Wriedt, Mario,Ye?ilel, Okan Zafer
, (2021)
Four new coordination polymers, formulated as {[MnCl(μ-bipna)](NO3)?2H2O}n (1), {[CoCl2(μ-bipna)]?2H2O}n (2), {[CuCl(μ4-bipna)]BF4?2H2O}n (3) and {[CuCl(μ4-bipna)]ClO4?2H2O}n (4) where H2bipnaBr2 = 1,1′-(1,1′-biphenyl-4,4′-diylbis(methylene))bis(3-carboxypyridin-1-ium) bromide, were synthesized under solvothermal conditions. Their structures have been characterized by single crystal and powder X-ray diffraction analyses, infrared spectra (IR) and elemental analyses. Complexes 1, 3 and 4 are isostructural and display 3-fold interpenetrated 2D → 2D structures with sql topology and the point symbol 44.62. Complex 2 exhibits a 1D coordination polymer structure, which becomes a stacked 3D supramolecular structure by hydrogen bonding and π???π interactions. The structural diversity of the compounds could be due to the conformation of the flexible zwitterionic ligands. In 2, the bipna ligand displays a cis-conformation, while in the other compounds the ligand shows a trans-conformation. The thermal and optical properties of the compounds were investigated.
Silver Nanoparticles Architectured HMP as a Recyclable Catalyst for Tetramic Acid and Propiolic Acid Synthesis through CO2 Capture at Atmospheric Pressure
Ghosh, Swarbhanu,Ghosh, Aniruddha,Riyajuddin, Sk,Sarkar, Somnath,Chowdhury, Arpita Hazra,Ghosh, Kaushik,Islam, Sk. Manirul
, p. 1055 - 1067 (2020/01/21)
The recent advancement on the tailored synthesis of hypercrosslinked microporous polymer (HMP-2) has assembled significant concentration by the virtue of its adjustable porosity, operative design and absolutely ordering structure. This perfectly structured Ag NPs supported carbocatalyst (Ag-HMP-2) has been synthesized by Friedel-Crafts alkylation between 4,4′-Bis(bromomethyl)-1,1′-biphenyl and carbazole over anhydrous iron(III)chloride catalysis followed by the appending of the silver nanoparticles (Ag NPs) onto the material. The silver nanoparticle was decorated over the HMP-2 to prepare the corresponding catalyst (Ag-HMP-2). The characterization of the newly produced material has been conducted by N2 adsorption/desorption studies, XPS, FE-SEM, transmission electron microscopy (TEM) and Powder X-ray diffraction (PXRD) methods. This microporous catalyst has spectacular activities for the production of tetramic acids from various types of propargylic amine derivatives at 60 °C under atmospheric carbon dioxide pressure. Parallel attempt on fixation of CO2 was executed over terminal alkynes to synthesize propiolic acids under 1 atm pressure. The catalyst (Ag-HMP-2) exhibited sufficient recycling ability for the generation of tetramic acids and propiolic acids up to five catalytic runs without reduction in its catalytic activity.
Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands
Sakyiamah, Maxwell M.,Kobayakawa, Takuya,Fujino, Masayuki,Konno, Makoto,Narumi, Tetsuo,Tanaka, Tomohiro,Nomura, Wataru,Yamamoto, Naoki,Murakami, Tsutomu,Tamamura, Hirokazu
supporting information, p. 1130 - 1138 (2019/02/16)
The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis. With the aim of enhancing the binding affinity and anti-HIV activity of a potent CXCR4 ligand as a lead, 23 low molecular weight compounds containing dipicolylamine (Dpa) and cyclam cationic moieties with varying spacers and spatial positioning were designed, synthesized and biologically evaluated. All of the synthesized compounds screened at 1.0 μM in the NanoBRET assay system exhibited >70% inhibition of the binding of a competitive probe TAMRA-Ac-TZ14011 (10 nM) to CXCR4 in the presence of zinc (II) ion. Furthermore, selected compounds 3, 8, 9, 19 and 21 with spatial distances between the next carbon to Dpa and the next carbon to cyclam within the range of 6.5–7.5 ? showed potent binding affinity selective for CXCR4 with IC50 values of 1.6, 7.9, 5.7, 3.5 and 4.5 nM, respectively, with corresponding high anti-HIV activity with EC50s of 28, 13, 21, 28 and 61 nM, respectively, in the presence of zinc (II) ion. Some compounds with remarkably more potent CXCR4-binding affinity than that of an initial lead were obtained. These compounds interact with different but overlapping amino acid residues of CXCR4. The present studies have developed new low molecular weight CXCR4 ligands with high CXCR4-binding and anti-HIV activities, which open avenue into the development of more potent CXCR4 ligands.
Substituent effect on the photochemical and photophysical properties of 4,4′-distyrylbiphenyl derivatives
Sakurai, Hiroya,Arai, Tatsuo
supporting information, p. 1337 - 1339 (2017/12/26)
Photochemical properties of 4,4′-distyrylbiphenyl (DSBP) derivatives have been studied. While the introduction of methoxy groups at meta-positions does not influence the photoisomerization of DSBP, the introduction of methyl substituents at the biphenyl moiety (MDSBP) changed the photoisomerization from one-way cis-to-trans photoisomerization for DSBP to cistrans mutual photoisomerization for MDSBP.
PROCESS FOR PREPARING ARYL KETONE
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Paragraph 0171; 0172, (2017/06/12)
A process for preparing aryl ketones is disclosed. The process includes photo-oxidizing a compound of formula (V), (VI), (VII) or (VIII): in the presence of an oxidative system comprising at least one bromide compound to form aryl ketones. X1, X2, R1, R2, R3, L1, L2, L3, L4, t, n, m and p have the meanings as described in the specification and claims.
Dendritic effect on the photoisomerization of 4,4′-distyrylbiphenyl in aqueous solution
Sakurai, Hiroya,Arai, Tatsuo
supporting information, p. 911 - 913 (2016/10/26)
Newly synthesized 4,4′-distyrylbiphenyl-cored water-soluble dendrimers underwent trans-to-cis photoisomerization, while the core 4,4′-distyrylbiphenyl underwent cis-to-trans one-way photoisomerization.
Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors
Rubio-Ruíz, Belén,Conejo-García, Ana,Ríos-Marco, Pablo,Carrasco-Jiménez, María Paz,Segovia, Josefa,Marco, Carmen,Gallo, Miguel A.,Espinosa, Antonio,Entrena, Antonio
body text, p. 154 - 162 (2012/07/14)
Inhibition of Choline Kinase (ChoK) has been reported as a therapeutical target in the treatment of some kinds of tumor. In this paper, the design and synthesis of new non-symmetrical monocationic ChoK inhibitors is described, bearing a cationic head and an adenine moiety connected by linkers of different lengths. Docking studies indicate that the cationic head of these compounds could be inserted into the choline binding site of the enzyme, while the adenine moiety could be stabilized into the ATP binding site. Docking studies also support the difference of activity of the synthesized compounds, which depends on both the substituent at position 4 of the cationic head and the linker length, being dimethylamine and 1,4-diphenylbutane respectively, the most appropriate ones. Compounds 14 (IC50 = 10.70 ± 0.40 μM) and 17 (IC50 = 6.21 ± 0.97 μM) are the most potent ChoK inhibitors and suitable for further modification with a view to obtain more potent antitumor compounds.
TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS
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, (2011/04/18)
The present invention relates to a time temperature indicator for indicating a temperature change over time comprising one dimeric or trimeric spiropyran indicator of the formula I or II wherein R1-R4 independently of one another is hydrogen, —C1C6 alkoxy, halogen, CF3, —C1C6 alkyl or —NO2, R5 is hydrogen, halogen, —C1-C6 alkoxy, —COOH, —COO—C1-C6 alkyl, —CF3 or phenyl; R11 is hydrogen or R11 and R5 form together a phenyl ring; Ra is —C1-C6 alkyl Rb is —C1-C6 alkyl, or together with Ra form a 5-6 membered ring L is a divalent linker; L′ is a trivalent linker.
