20254-76-6

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloroquinoxaline-2-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antiproliferative properties. It plays a crucial role in the development of new drugs that can target and inhibit the growth of harmful microorganisms and cancer cells.
Used in Agrochemical Industry:
3-Chloroquinoxaline-2-carboxylic acid is used as an intermediate in the synthesis of agrochemicals, particularly those with antimicrobial properties. Its application in this industry helps in the development of effective pesticides and fungicides to protect crops from diseases and pests, ensuring better yield and quality.
Used in Medicinal Chemistry Research:
3-Chloroquinoxaline-2-carboxylic acid is used as a valuable compound in medicinal chemistry research for its potential to be developed into new drugs. Researchers explore its chemical properties and interactions with biological systems to design and synthesize novel therapeutic agents with improved efficacy and selectivity.
Used in Chemical Synthesis:
3-Chloroquinoxaline-2-carboxylic acid is used as a key building block in the chemical synthesis of various organic compounds. Its unique structure and functional groups make it a versatile component in the synthesis of complex molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 49679-45-0 ethyl 3-chloroquinoxaline-2-carboxylate 
• 32601-86-8 2-chloro-3-methylquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 
• 23395-75-7 ethyl 2-quinoxalinecarboxylate 4-oxide 
• 7065-23-8 ethyl quinoxaline-2-carboxylate 

Downstream Products

• 49679-41-6 3-chloroquinoxaline-2-carbonyl chloride 
• 1402573-35-6 C₂₁H₁₉F₃N₄O₂ 
• 1402573-31-2 C₂₀H₂₀N₄O₂ 
• 1402573-32-3 C₂₁H₂₂N₄O₃ 
• 1402573-33-4 C₂₁H₂₂N₄O₃ 
• 1402573-34-5 C₂₀H₁₉ClN₄O₂ 
• 55495-69-7 3-methoxyquinoxalin-2-carboxylic acid 
• 1422642-94-1 1-cyclohexyl-2-phenylpyrido[2,3-b]quinoxalin-4(1H)-one 
• 1422642-92-9 3-(4-tert-butylphenyl)-1-(3-chloroquinoxalin-2-yl)prop-2-yn-1-one 

Relevant academic research and scientific papers

Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist

A series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin3 (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA2 6.4) to that of standard antagonist Ondansetron (pA2 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities.

Ligand-based design, synthesis, and pharmacological evaluation of 3-methoxyquinoxalin-2-carboxamides as structurally novel serotonin type-3 receptor antagonists

Employing a ligand-based approach, 3-methoxyquinoxalin-2-carboxamides were designed as serotonin type-3 (5-HT3) receptor antagonists and synthesized from the starting material o-phenylenediamine in a sequence of reactions. The structures of the

Discovery of new anti-depressants from structurally novel 5-HT3 receptor antagonists: Design, synthesis and pharmacological evaluation of 3-ethoxyquinoxalin-2-carboxamides

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquin

Pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinoxalin-4(1H)-one: Synthesis and characterization of a novel tetracyclic ring system

(Chemical Equation Presented) Derivatives of the hitherto unknown ring system, pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinoxalin-4(1H)-one, are synthesized in one step from the corresponding 1-substuituted or 1,3-disubstituted 2-pyrazolin-5-ones and 3-chloroquinoxaline-2-carbonyl chloride using calcium hydroxide in boiling 1,4-dioxane. The parent system carrying no substituent in positions 1 and 3 is obtained upon treatment of the 1-PMB (p-methoxybenzyl) protected congener with trifluoroacetic acid. Detailed NMR spectroscopic investigations including unambiguous chemical shift assignments of all 1H, 13C, and 15N resonances of the obtained tetracycles are reported.