57315-47-6Relevant articles and documents
Efficient synthesis of quinoxaline derivatives by selective modification of 3-chloro-6-fluoroquinoxalin-2(1H)-one 4-oxide
Maichrowski, Jan,Gjikaj, Mimoza,Huebner, Eike G.,Bergmann, Baerbel,Mueller, Ingrid B.,Kaufmann, Dieter E.
, p. 2091 - 2105 (2013)
The readily available and polyfunctionalized 3-chloro-6-fluoroquinoxalin- 2(1H)-one 4-oxide, derived from the efficient one-step annulation reaction of 1,1,2-trichloro-2-nitroethene with 4-fluoroaniline, was selectively modified at the chloronitrone and the amide units, leading to more than 30 new quinoxaline derivatives with a unique substitution pattern in good to excellent yields. In addition, the electronic properties of the versatile starting compound were computed by means of density functional theory, which gave a reasonable explanation for its unique reactivity. The antimalarial activity of all hitherto unknown compounds has been investigated. The polyfunctionalized 3-chloro-6-fluoroquinoxalin-2(1H)-one 4-oxide was selectively modified at the chloronitrone and the amide units. More than 30 new quinoxaline derivatives with a unique substitution pattern were synthesized in good to excellent yields. In addition, their antimalarial activity was screened. Copyright
Kinetics of solvolysis of 2-chloroquinoxaline
Patel
, p. 403 - 406 (2007/10/03)
Pseudo-first-order rate constants and activation parameters have been measured for the solvolysis of 2-chloroquinoxaline in various aquo-organic mixtures using methanol, ethanol, and isopropanol as the organic solvent. Excellent linear correlations are found between lnk and the mol fraction of cosolvent and In[H2O]. The medium effect on the rates of solvolysis is assessed by Grunwald-Winstein's mY correlationship. the estimated values of m (0.55-0.72) and the entropy of activation (148-212 J deg-1 mol-1) for the reactions are well in the range for a bimolecular aromatic substitution reactions.
