7065-23-8

Basic information

• Product Name: ETHYL 2-QUINOXALINECARBOXYLATE
• Synonyms: ETHYL 2-QUINOXALINECARBOXYLATE;2-Quinoxalinecarboxylic acid ethyl ester
• CAS NO: 7065-23-8
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Quinoxalines
• Mol File: 7065-23-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 81-83 °C(lit.)
• Boiling Point: 506.3°Cat760mmHg
• Flash Point: 260°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 2.26E-10mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 2-QUINOXALINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-QUINOXALINECARBOXYLATE(7065-23-8)
• EPA Substance Registry System: ETHYL 2-QUINOXALINECARBOXYLATE(7065-23-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 7065-23-8(Hazardous Substances Data)

Usage

Uses

Ethyl 2-quinoxalinecarboxylate may be used in chemical synthesis studies.

InChI:InChI=1/C25H34N4O3S2/c1-7-8-9-28-22(27-13-16(4)32-17(5)14-27)19(18(6)20(11-26)23(28)30)10-21-24(31)29(12-15(2)3)25(33)34-21/h10,15-17H,7-9,12-14H2,1-6H3

Upstream product

• 54745-92-5 quinoxaline-2-carboxylic acid chloride 
• 64-17-5 ethanol 
• 95-54-5 1,2-diamino-benzene 
• 1865-11-8 quinoxaline-2-carboxylic acid methyl ester 
• 1593-08-4 Quinoxaline-2-carboxaldehyde 
• 879-65-2 quinoxaline-2-carboxylic acid 
• 4711-06-2 (1R,2S,3R)-1-(quinoxalin-2-yl)butane-1,2,3,4-tetraol 
• 138380-46-8 3,3-Dihydroxy-2-oxo-propionic acid ethyl ester 

Downstream Products

• 1593-08-4 Quinoxaline-2-carboxaldehyde 
• 879-65-2 quinoxaline-2-carboxylic acid 
• 54571-06-1 quinoxaline-2-carbohydrazide 
• 23395-75-7 ethyl 2-quinoxalinecarboxylate 4-oxide 
• 49679-45-0 ethyl 3-chloroquinoxaline-2-carboxylate 
• 20254-76-6 3-Chloroquinoxaline-2-carboxylic acid 

Relevant articles and documents

Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors

Herein we report a microscale parallel synthetic approach allowing for rapid access to libraries of N-acylated aminotriazoles and screening of their inhibitory activity against factor XIIa (FXIIa) and thrombin, which are targets for antithrombotic drugs. This approach, in combination with post-screening structure optimization, yielded a potent 7 nM inhibitor of FXIIa and a 25 nM thrombin inhibitor; both compounds showed no inhibition of the other tested serine proteases. Selected N-acylated aminotriazoles exhibited anticoagulant properties in vitro influencing the intrinsic blood coagulation pathway, but not extrinsic coagulation. Mechanistic studies of FXIIa inhibition suggested that synthesized N-acylated aminotriazoles are covalent inhibitors of FXIIa. These synthesized compounds may serve as a promising starting point for the development of novel antithrombotic drugs.

Sodium cyanoborohydride-mediated direct conversion of some heterocyclic aldehydes to esters

An exceptional oxidizing behavior of sodium cyanoborohydride is observed where electron-withdrawing heterocyclic aldehydes are directly converted to their corresponding esters on treatment of sodium cyanoborohydride in methanol. The spectral analysis and

Oxidation of diazo compounds by dimethyl dioxirane: An extremely mild and efficient method for the preparation of labile α-oxo-aldehydes

A novel method for the preparation of α-oxo-aldehydes by dimethyl dioxirane oxidation of α-diazoketones is described. The procedure is particularly useful when the desired compound cannot be purified by chromatography or distillation: the by-products (ace