20292-15-3

Upstream product

• 64-17-5 ethanol 
• 4342-60-3 4-methylcyclohex-3-enecarboxylic acid 
• 90113-39-6 3-hydroxy-4-methyl-cyclohexanecarboxylic acid 
• 917-64-6 methyl magnesium iodide 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 140-88-5 ethyl acrylate 
• 78-79-5 isoprene 
• 90113-41-0 4-hydroxy-4-methylcyclohexane-1-carboxylic acid 
• 145576-28-9 ethyl 4-methylidenecyclohexanecarboxylate 
• 42216-96-6 triethyl orthoacrylate 

Downstream Products

• 4342-60-3 4-methylcyclohex-3-enecarboxylic acid 
• 39155-38-9 (4-methylcyclohex-3-en-1-yl)methanol 
• 7086-66-0 2-<(1RS)-4-methylcyclohex-3-enyl>acetic acid 
• 18240-10-3 (+/-)-2-(3-cyclohexenyl)ethanol 
• 53216-76-5 4-Methyl-3-cyclohexen-1-acetonitril 
• 7086-72-8 4-methyl-3-cyclohexene-1-acetyl chloride 
• 1262321-66-3 C₁₇H₂₂O₂S 
• 1296939-13-3 C₁₇H₂₄O₃ 
• 1296939-12-2 C₁₆H₂₂O₃ 
• 1537877-76-1 C₁₇H₂₀N₂O 
• 1537877-75-0 C₁₆H₁₉F₃O 
• 1537877-74-9 C₁₄H₁₈S 

Relevant academic research and scientific papers

Isotope effects for lewis acid catalyzed Diels-Alder reactions. The experimental transition state

2H and 13C kinetic isotope effects were determined for all positions on isoprene in its reactions with methyl vinyl ketone, ethyl acrylate, and acrolein catalyzed by Et2AlCl. The results are taken as supporting a highly asynchronous concerted [4+2] cycloaddition. Comparison of the experimental isotope effects with calculated values supports this conclusion and the accuracy of the calculated transition structure.

Compound and preparation method and application thereof

The invention discloses a compound as well as a preparation method and application thereof, and the structural formula of the compound is as shown in formula 1. The research finds that the compound provided by the invention can be applied to preparation o

Cobalt-Catalyzed Regioselective Olefin Isomerization under Kinetic Control

Olefin isomerization is a significant transformation in organic synthesis, which provides a convenient synthetic route for internal olefins and remote functionalization processes. The selectivity of an olefin isomerization process is often thermodynamically controlled. Thus, to achieve selectivity under kinetic control is very challenging. Herein, we report a novel cobalt-catalyzed regioselective olefin isomerization reaction. By taking the advantage of fine-tunable NNP-pincer ligand structures, this catalytic system features high kinetic control of regioselectivity. This mild catalytic system enables the isomerization of 1,1-disubstituted olefins bearing a wide range of functional groups in excellent yields and regioselectivity. The synthetic utility of this transformation was highlighted by the highly selective preparation of a key intermediate for the total synthesis of minfiensine. Moreover, a new strategy was developed to realize the selective monoisomerization of 1-alkenes to 2-alkenes dictated by installing substituents on the γ-position of the double bonds. Mechanistic studies supported that the in situ generated Co-H species underwent migratory insertion of double bond/β-H elimination sequence to afford the isomerization product. The less hindered olefin products were always preferred in this cobalt-catalyzed olefin isomerization due to an effective ligand control of the regioselectivity for the β-H elimination step.

Polyelectrolyte-catalyzed Diels–Alder reactions

Imidazolium-based poly(ionic liquids) bearing bromide and bis(trifluoromethane)sulfonimide as counteranions [poly(ViEIm)Br and poly(ViEIm)NTf2] derived from reversible addition fragmentation chain transfer (RAFT) polymerization techniques are u

Lewis Acids as Activators in CBS-Catalysed Diels–Alder Reactions: Distortion Induced Lewis Acidity Enhancement of SnCl4

The effect of several Lewis acids on the CBS catalyst (named after Corey, Bakshi and Shibata) was investigated in this study. While2H NMR spectroscopic measurements served as gauge for the activation capability of the Lewis acids, in situ FT-IR spectroscopy was employed to assess the catalytic activity of the Lewis acid oxazaborolidine complexes. A correlation was found between the Δδ(2H) values and rate constants kDA, which indicates a direct translation of Lewis acidity into reactivity of the Lewis acid–CBS complexes. Unexpectedly, a significant deviation was found for SnCl4as Lewis acid. The SnCl4–CBS adduct was much more reactive than the Δδ(2H) values predicted and gave similar reaction rates to those observed for the prominent AlBr3–CBS adduct. To rationalize these results, quantum mechanical calculations were performed. The frontier molecular orbital approach was applied and a good correlation between the LUMO energies of the Lewis acid–CBS–naphthoquinone adducts and kDAcould be found. For the SnCl4–CBS–naphthoquinone adduct an unusual distortion was observed leading to an enhanced Lewis acidity. Energy decomposition analysis with natural orbitals for chemical valence (EDA-NOCV) calculations revealed the relevant interactions and activation mode of SnCl4as Lewis acid in Diels–Alder reactions.

Simple, chemoselective hydrogenation with thermodynamic stereocontrol

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

Diels-alder reaction in air-and moisture-stable zinc-containing ionic liquids

Diels-Alder reactions in a number of air- and moisture-stable dialkylimidazolium halide-ZnCl2 ionic liquids are reported. High yields and high endo selectivities have been observed. The ionic liquids could then be recyclable without loss of reactivity.

Study of the inhibiting activity of 4-(4′-hydroxyphenyl)-and 4-(2′-hydroxy-5′-methylphenyl)methyl cyclohexane carboxylic acid ethyl esters in photooxidation of petroleum phosphors

4-(4′-hydroxyphenyl)-and 4-(2′-Hydroxy-5′-methylphenyl) methyl cyclohexane carboxylic acid ethyl esters were synthesized from phenol and para-cresol. The structure of the esters synthesized was studied, and their inhibiting activity in photooxidation of a

Erbium triflate in ionic liquids: A recyclable system of improving selectivity in Diels-Alder reactions

The efficiency of Er(OTf)3 in promoting the Diels-Alder reactions between different dienes and dienophiles in ionic liquids has been investigated. Compared with the analogous cycloadditions performed in conventional solvents shorter reaction times are required to obtain good/excellent yields. In most cases an enhancement of regio- and endo:exo selectivity was observed. The role of the ionic liquid, as a function of the cationic part, i.e. the imidazolium based or the pyridinium based, is discussed well. The ILs containing the catalyst can be readily separated from the reaction products and recovered in very high purity for direct reuse, up to six cycles.

2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS

Anti-viral agents of compounds of Formula (I): wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.