2030-45-7Relevant academic research and scientific papers
SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists
Atobe, Masakazu,Naganuma, Kenji,Kawanishi, Masashi,Morimoto, Akifumi,Kasahara, Ken-Ichi,Ohashi, Shigeki,Suzuki, Hiroko,Hayashi, Takahiko,Miyoshi, Shiro
, p. 6569 - 6576 (2014/01/06)
We describe a medicinal chemistry approach for generating a series of 2-(1H-pyrazol-1-yl)thiazoles as EP1 receptor antagonists. To improve the physicochemical properties of compound 1, we investigated its structure-activity relationships (SAR).
A new synthesis of 2-aroylcoumaran-3-ones by hypervalent iodine oxidation of 2-acetyl-phenyl benzoates using [hydroxy(tosyloxy)iodo]benzene
Prakash,Goyal
, p. 629 - 630 (2007/10/02)
Hypervalent iodine oxidation of 2-acetylphenyl benzoates 1 a-f using [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by Baker-Venkatraman rearrangement of the resultant 2-[(tosyloxy)acetylphenyl benzoates 2a-f with potassium hydroxide, provides a new conv
Reactions of Flav-2-enes and Flav-2-en-4-ones (Flavones)
Bird, T. Geoffrey C.,Brown, Ben R.,Stuart, Ian A.,Tyrrell, William R.
, p. 1831 - 1846 (2007/10/02)
Flav-2-enes, flavones, and 3-alkyl ethers of flavonols add alcohols and carboxylic acids in the presence of N-bromosuccinimide to give 2-alkoxy- and 2-acyloxy-3-bromoflavans which provide routes to cis-3-bromoflavans by reduction and to 3,4-diols by elimination and reaction with osmium tetraoxide.The 2-acyloxyflavans react with alcohols yielding 2-alkoxyflavans.Flavonols react with N-bromosuccinimide and alcohols to give bromine-free hemiacetals, the known 2,3-dialkoxy-3-hydroxyflavanones.
Synthesis of 1-Phenyl-3-aryl-benzofuranopyrazoles
Joshi, M. G.,Wadokar, K. N.
, p. 930 - 931 (2007/10/02)
Iodination of o-aroyloxyacetophenones (Ia-f) with iodine monochloride in acetic acid affords ω-iodo-2-aroyloxy-acetophenones (IIa-f) which on base catalysed Baker-Venkataraman transformation afford 2-aroylcoumaran-3-ones (IIIa-f).Compounds (IIIa-f) on ref
