203115-93-9Relevant articles and documents
Mechanistic Insight Leads to a Ligand Which Facilitates the Palladium-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles
Olsen, Esben P. K.,Arrechea, Pedro L.,Buchwald, Stephen L.
supporting information, p. 10569 - 10572 (2017/08/22)
By using mechanistic insight, a new ligand (EPhos) for the palladium-catalyzed C?N cross-coupling between primary amines and aryl halides has been developed. Employing an isopropoxy group at the C3-position favors the C-bound isomer of the ligand-supported palladium(II) complexes and leads to significantly improved reactivity. The use of a catalyst system based on EPhos with NaOPh as a mild homogeneous base proved to be very effective in the formation of 4-arylaminothiazoles and highly functionalized 2-arylaminooxazoles. Previously, these were not readily accessible using palladium catalysis.
Practical synthesis of aromatic ethers by SNAr of fluorobenzenes with alkoxides
Rodriguez, Juan R.,Agejas, Javier,Bueno, Ana B.
, p. 5661 - 5663 (2007/10/03)
Aromatic fluorines have been substituted by alkoxides in a variety of activated and unactivated aromatic systems.
