20317-40-2

Basic information

• Product Name: METHYL 4-ISOQUINOLINECARBOXYLATE
• Synonyms: METHYL 4-ISOQUINOLINECARBOXYLATE;4-Isoquinolinecarboxylic acid, methyl ester;methyl isoquinoline-4-carboxylate
• CAS NO: 20317-40-2
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Mol File: 20317-40-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 82℃
• Boiling Point: 315.263°C at 760 mmHg
• Flash Point: 144.466°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: METHYL 4-ISOQUINOLINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-ISOQUINOLINECARBOXYLATE(20317-40-2)
• EPA Substance Registry System: METHYL 4-ISOQUINOLINECARBOXYLATE(20317-40-2)

Safety Data

• Hazardous Substances Data: 20317-40-2(Hazardous Substances Data)

Usage

General Description

Methyl 4-isoquinolinecarboxylate, also known as methylisoquinoline-4-carboxylate, is a chemical compound with the molecular formula C11H9NO2. It is a derivative of isoquinoline and is commonly used in the pharmaceutical industry for the synthesis of various drugs and drug intermediates. METHYL 4-ISOQUINOLINECARBOXYLATE has a range of potential biological activities and is often studied for its potential therapeutic applications, particularly in relation to its possible antitumor and anti-inflammatory properties. Methyl 4-isoquinolinecarboxylate is also used as a building block in organic synthesis, enabling the creation of new compounds and materials with diverse properties and applications.

InChI:InChI=1/C11H9NO2/c1-14-11(13)10-7-12-6-8-4-2-3-5-9(8)10/h2-7H,1H3

Upstream product

• 67-56-1 methanol 
• 685103-98-4 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline 
• 201230-82-2 carbon monoxide 
• 119-65-3 isoquinoline 
• 7159-36-6 4-isoquinolinecarboxylic acid 
• 34846-65-6 isoquinoline-4-carbonitrile 
• 34784-02-6 3-bromoisoquinoline 
• 370580-85-1 C₁₀H₆ClNO 
• 1532-97-4 4-bromoisoquinoline 

Downstream Products

• 116140-19-3 1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid 

Relevant articles and documents

Pd(0)-mediated [11C]carbonylation of aryl and heteroaryl boronic acid pinacol esters with [11C]carbon monoxide under ambient conditions and a facile process for the conversion of [carbonyl-11C]esters to [carbonyl-11C]amides

A new method has been developed for the Pd(0)-mediated [11C]carbonylation of aryl/heteroaryl boronic acid pinacol esters with [11C]carbon monoxide in the presence of p-benzoquinone and triphenylphosphine in a mixture of N,N-dimethylformamide (DMF) and methanol (MeOH) or just MeOH under ambient pressure at 65 °C. This method was used to convert a variety of different aryl/heteroaryl boronates to the corresponding [carbonyl-11C]esters with decay-corrected radiochemical yields in the range of 6-80%. Furthermore, some of these [carbonyl-11C]esters were treated with sodium hydroxide or aqueous ammonium to give the corresponding [carbonyl-11C]carboxylic acids and amides, respectively. This new method was also used to achieve the direct syntheses of [11C]aspirin using water or tetramethylammonium hydroxide as the nucleophile instead of MeOH in DMF.

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel anabaseine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods- of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from