20320-35-8

Usage

Uses

Used in Pharmaceutical Industry:
2-[(TERT-BUTYLAMINO)CARBONYL]BENZOIC ACID is used as a reagent for the synthesis of various pharmaceuticals due to its ability to modify the activity of enzymes and proteins. Its unique chemical structure allows it to interact with biological targets, making it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 2-[(TERT-BUTYLAMINO)CARBONYL]BENZOIC ACID is utilized as a reagent for the preparation of agrochemicals. Its properties enable it to be incorporated into compounds that can enhance crop protection and improve agricultural productivity.
Used as an Enzyme and Protein Modifier:
2-[(TERT-BUTYLAMINO)CARBONYL]BENZOIC ACID is used as an enzyme and protein modifier to study its effects on biological systems. Its ability to interact with enzymes and proteins makes it a useful tool in understanding the mechanisms of action and potential applications in therapeutic interventions.
Used in Therapeutic Research:
2-[(TERT-BUTYLAMINO)CARBONYL]BENZOIC ACID is used in therapeutic research for the treatment of various diseases and conditions. Its potential therapeutic properties are being investigated to identify new avenues for drug development and to improve patient outcomes.

InChI:InChI=1/C12H15NO3/c1-12(2,3)13-10(14)8-6-4-5-7-9(8)11(15)16/h4-7H,1-3H3,(H,13,14)(H,15,16)/p-1

Upstream product

• 85-44-9 phthalic anhydride 
• 75-64-9 tert-butylamine 
• 601-70-7 3,3-dichlorophthalide 
• 88-67-5 2-Iodobenzoic acid 
• 64-18-6 formic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 56475-12-8 3-(tert-butylimino)isobenzofuran-1(3H)-one 

Downstream Products

• 56475-12-8 3-(tert-butylimino)isobenzofuran-1(3H)-one 

Relevant academic research and scientific papers

Fluorescent probe for screening drugs acting on ryanodine receptor

The invention discloses a fluorescent probe for screening drugs acting on a ryanodine receptor. The structural formula of the probe is shown as a formula (I) which is described in the specification. The fluorescent probe for screening the drug acting on the ryanodine receptor can directly and specifically bind to a ryanodine receptor existing in a cell system of an insect, and can be replaced by other drugs binding to the ryanodine receptor of the insect, so the fluorescent probe can be used for screening drugs interacting with the ryanodine receptor of the insect.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O

Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

Facile syntheses and characterization of hyperbranched poly(ester-amide)s from commercially available aliphatic carboxylic anhydride and multihydroxyl primary amine

A new method for synthesis of novel hyperbranched poly(ester-amide)s from commercially available AA′ and CBx type monomers has been developed on the basis of a series of model reactions. The hyperbranched poly(ester-amide)s with multihydroxyl end groups are prepared by thermal polycondensation of carboxyl anhydrides (AA′) and multihydroxyl primary amine (CBx) without any catalyst and solvent. The reaction mechanism in the initial stage of polymerization was investigated with in situ 1H NMR. In the initial stage of the reaction, primary amino groups of 2-amino-2-ethyl-1,3-propanediol (AEPO) or tris(hydroxymethyl)aminomethane (THAM) react rapidly with anhydride, forming an intermediate which can be considered as a new ABx type monomer. Further self-polycondensation reactions of the ABx molecules produce hyperbranched polymers. Analysis using 1H and 13C NMR spectroscopy revealed the degree of branching of the resulting polymers ranging from 0.36 to 0.55. These hyperbranched poly(ester-amide)s contain configurational isomers observed by 13C and DEPT 13C NMR spectroscopy, possess high molecular weights with broad distributions and display glass-transition temperatures (Tgs) between 7 and 96°C. The thermogravimetric analytic measurements revealed the decomposition temperature at 10% weight-loss temperatures (Td10%) ranging from 212 to 325°C. Among the hyperbranched poly(ester-amide)s obtained, the polymers with cyclohexyl molecular skeleton structure exhibit the lowest branching degree, the highest glass-transition temperatures, and the best thermal stability.

The reaction of phthalidylidene dichloride with primary amines. Synthesis and X-ray molecular structure of N-substituted phthalisoimides

An efficient method for the synthesis of N-substituted phthalisoimides, by reaction of phthalidylidene dichloride with primary amines, is described. The reactions with arylamines, arylenediamincs and alkylenediamines lead to the corresponding phthalisoimides or bisphthalisoimides in nearly quantitative yields. However, the reactions with alkylamines are not useful because of the relatively high nucleophilicity of alkylamines. Certain particular behaviours of arylamines, associated with the presence of specific ortho-substituents have been found. The reactions of arylamines bearing an o-hydroxymethyl group provide a convenient method for preparing 2-benzoxazinylbenzoic acids. The X-ray crystallographic structures of N-(2-methoxyphenyl)phthalisoimide 3a and 2-(4H-3.1-benzoxazin-2-yl)benzoic acid 15a have been determined.