20320-35-8Relevant articles and documents
Fluorescent probe for screening drugs acting on ryanodine receptor
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Paragraph 0047-0052, (2020/11/02)
The invention discloses a fluorescent probe for screening drugs acting on a ryanodine receptor. The structural formula of the probe is shown as a formula (I) which is described in the specification. The fluorescent probe for screening the drug acting on the ryanodine receptor can directly and specifically bind to a ryanodine receptor existing in a cell system of an insect, and can be replaced by other drugs binding to the ryanodine receptor of the insect, so the fluorescent probe can be used for screening drugs interacting with the ryanodine receptor of the insect.
Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O
Kaicharla, Trinadh,Thangaraj, Manikandan,Biju, Akkattu T.
supporting information, p. 1728 - 1731 (2014/04/17)
Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.
The reaction of phthalidylidene dichloride with primary amines. Synthesis and X-ray molecular structure of N-substituted phthalisoimides
Guirado, Antonio,Zapata, Andres,Ramirez De Arellano, M. Carmen
, p. 5305 - 5324 (2007/10/03)
An efficient method for the synthesis of N-substituted phthalisoimides, by reaction of phthalidylidene dichloride with primary amines, is described. The reactions with arylamines, arylenediamincs and alkylenediamines lead to the corresponding phthalisoimides or bisphthalisoimides in nearly quantitative yields. However, the reactions with alkylamines are not useful because of the relatively high nucleophilicity of alkylamines. Certain particular behaviours of arylamines, associated with the presence of specific ortho-substituents have been found. The reactions of arylamines bearing an o-hydroxymethyl group provide a convenient method for preparing 2-benzoxazinylbenzoic acids. The X-ray crystallographic structures of N-(2-methoxyphenyl)phthalisoimide 3a and 2-(4H-3.1-benzoxazin-2-yl)benzoic acid 15a have been determined.
