20321-33-9

Upstream product

• 3979-57-5 (3,4-dimethoxy-phenyl)-acetic acid-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamide] 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 98-88-4 benzoyl chloride 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 1122570-47-1 2-benzoyl-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3-methyl-1,2-dihydroisoquinoline-1-carbonitrile 
• 120-26-3 2-(3,4-dimethoxyphenyl)-1-methylethylamine 

Downstream Products

• 106053-22-9 α-Deutero-2-<β-deutero-(β-N-ethoxycarbonyl-N-methyl-aminoethyl)-β-methyl>-3',4,4',5-tetramethoxystilben 
• 106053-21-8 2-<(β-N-Ethoxycarbonyl-N-methyl-aminoethyl)-β-methyl>-3',4,4',5-tetramethoxystilben 
• 106053-20-7 1,3-Dideutero-3-methyllaudanosin 
• 106053-19-4 3-Methyllaudanosin 

Relevant academic research and scientific papers

Synthesis of 6-methyl-8H-dibenzo[a,g]quinolizin-8-imines via Reissert compounds

Alkylation of Reissert compounds derived from 3-methylisoquinolines with several 2-cyanobenzylbromides followed by hydrolytic cleavage provided the corresponding 1-benzyl-3-methylisoquinolines. Treatment of the latter with methylmagnesiumiodide caused cyclization to the title compounds rather than formation of 2-acetylbenzylisoquinolines.

SYNTHESIS OF THE ALKALOID DIOXYLINE AND OTHER 6,7-DIMETHOXYISOQUINOLINES IN A MODIFIED RITTER REACTION

It has been found that aceto- and benzonitriles and 3,4-dimethoxyphenylacetone in the presence of acetylperchlorate or upon heating in polyphosphoric acid or polyphosphoric ester from the corresponding isoquinoline.The data indicate that the reaction proc