203263-28-9Relevant academic research and scientific papers
Synthesis of some novel cyanopyridines and isoxazoles bearing sulphonamide moiety and their antimicrobial activity
Patel, V. B.,Sorathiya, S. D.,Parikh, A. R.
, p. 822 - 825 (2007/10/03)
Substituted 2-propen-1-ones 2a-h, prepared by the reaction of p-(2,5-dichlorobenzenesulphonamido)acetophenone 1 with araldehydes, on condensation with malononitrile in the presence of ammonium accetate yield cyanopyridines 3a-h. Also 2a-h on reaction with hydroxylamine hydrochloride in the presence of sodium acetate in acetic acid afford isoxazoles 4a-h. The structures of 3a-h and 4a-h have been established on the basis of elemental analyses and spectral (IR, 1H NMR and mass) data. The products have been screened for their antimicrobial activity against various strains of bacteria and fungi.
