203645-40-3

Usage

Uses

Used in Pharmaceutical Industry:
(2S,5R)-5-phenylpyrrolidine-2-carboxylic acid is used as a key intermediate for the synthesis of various pharmaceuticals. Its chiral nature allows for the production of enantiopure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Organic Chemistry:
(2S,5R)-5-phenylpyrrolidine-2-carboxylic acid is used as a building block in organic chemistry for the synthesis of complex organic molecules. Its unique structure and functional groups enable the formation of a wide range of compounds with diverse applications in various industries.

Upstream product

• 124-38-9 carbon dioxide 
• 174311-02-5 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 221352-49-4 (2S,5R)-(tert-butyloxycarbonyl)-5-phenylpyrrolidine-2-carboxylic acid 

Downstream Products

• 226974-08-9 β-1-Phenyl-1,2,3,4-tetradeoxy-1,4-imino-D-pentitol 
• 744256-98-2 (2R,5S)-2-phenyl-5-trimethylsilanyloxymethyl-pyrrolidine 
• 744256-99-3 (2R,5S)-1-(4-chloro-benzenesulfonyl)-2-phenyl-5-trimethylsilanyloxymethyl-pyrrolidine 

Relevant academic research and scientific papers

A new sparteine surrogate for asymmetric deprotonation of N-Boc pyrrolidine

(Chemical Equation Presented) The s-BuLi complex of a cyclohexane-derived diamine is as efficient as s-BuLi/(-)-sparteine for the asymmetric deprotonation of N-Boc pyrrolidine. This is the first example of high enantioselectivity using a non-sparteine-like diamine in such reactions. The ( S, S)-diamine is a useful (+)-sparteine surrogate and was utilized in short syntheses of (-)-indolizidine 167B and an intermediate for the synthesis of the CCK antagonist (+)-RP 66803.

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther