226974-08-9

Upstream product

• 952-26-1 ethyl 5-phenylpyrrolidine-2-carboxylate 
• 98-79-3 L-Pyroglutamic acid 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 1611470-49-5 (S)-methyl 2-((tert-butoxycarbonyl)amino)-5-oxo-5-phenylpentanoate 
• 848132-13-8 methyl (2S)-5-phenyl-3,4-dihydro-2H-2-pyrrolecarboxylate 
• 4931-66-2 methyl (S)-pyroglutamate 
• 221352-49-4 (2S,5R)-(tert-butyloxycarbonyl)-5-phenylpyrrolidine-2-carboxylic acid 
• 203645-40-3 C₁₁H₁₃NO₂ 
• 830319-90-9 (5,5-dioxo-2,3S,5,9bR-tetrahydro-1H-5λ⁶-benzo[d]pyrrolo[1,2-b]isothiazol-3-yl)methanol 

Downstream Products

• 744256-98-2 (2R,5S)-2-phenyl-5-trimethylsilanyloxymethyl-pyrrolidine 
• 744256-99-3 (2R,5S)-1-(4-chloro-benzenesulfonyl)-2-phenyl-5-trimethylsilanyloxymethyl-pyrrolidine 

Relevant academic research and scientific papers

Synthesis of Bicyclic and Tricyclic Chiral Guanidinium Salts by an Intramolecular Alkylation Approach

Synthetic studies leading to three new types of chiral guanidinium scaffolds are described. Structures of interest include bicyclic guanidine derivatives with various substitution patterns around the guanidine core, as well as a highly rigid tricyclic scaffold. The challenging targets were accessed by application of mercury(II)-promoted guanylation of N-Boc-substituted thioureas and Ishikawa's desulfurative cyclization. In addition to our synthetic logics, a scalable synthesis of the tricyclic guanidinium salt is presented.

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther

Double reduction of cyclic aromatic sulfonamides: A novel method for the synthesis of 2- and 3-aryl-substituted cyclic amines

(Chemical Equation Presented) The facile double reduction of bicyclic aromatic sulfonamides was used to synthesize a variety of 2- and 3-aryl-substituted pyrrolidines and 2-phenylpiperidine. The method features a combined nitrogen protection and a traceless tether for the transposition of the aromatic moiety from nitrogen to carbon.

Convenient synthesis of C-aza-2,3-dideoxynucleosides

l-Aryl-l,2,3,4-tetradeoxy-l,4-imino-D-pentitols 5 and 9f are easily synthesized from TV-Boc-L-pyroglutamate 1 via a successive procedure involving regioselective ring-opening, recyclization with dehydration, stereoselective reduction, and reduction of the