203792-91-0Relevant academic research and scientific papers
Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety
Mack, Helmut,Baucke, Dorit,Hornberger, Wilfried,Lange, Udo E.W.,Seitz, Werner,Hoeffken, H. Wolfgang
, p. 2641 - 2647 (2008/12/21)
The synthesis and SAR of novel nanomolar thrombin inhibitors with the common backbone HOOC-CH2-d-cyclohexylalanyl-3,4-dehydroprolyl-NH-CH 2-aryl-C(double bond, long NH)NH2 are described together with their ecarin clotting
D-Phe-Pro-Arg type thrombin inhibitors: Unexpected selectivity by modification of the P1 moiety
Lange, Udo E. W.,Baucke, Dorit,Hornberger, Wilfried,Mack, Helmut,Seitz, Werner,Hoeffken, H. Wolfgang
, p. 2029 - 2033 (2007/10/03)
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray struc
