20380-17-0

Basic information

• Product Name: 21-bromo-17-hydroxypregn-4-ene-3,20-dione
• Synonyms: 21-Bromo-17-hydroxypregn-4-ene-3,20-dione; pregn-4-ene-3,20-dione, 21-bromo-17-hydroxy-
• CAS NO: 20380-17-0
• Molecular Formula: C₂₁H₂₉BrO₃
• Molecular Weight: 409.3572
• Mol File: 20380-17-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 529.6°C at 760 mmHg
• Flash Point: 274.1°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.99E-13mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 21-bromo-17-hydroxypregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 21-bromo-17-hydroxypregn-4-ene-3,20-dione(20380-17-0)
• EPA Substance Registry System: 21-bromo-17-hydroxypregn-4-ene-3,20-dione(20380-17-0)

Safety Data

• Hazardous Substances Data: 20380-17-0(Hazardous Substances Data)

Upstream product

• 106342-08-9 21-p-toluenesulfonate of 17α,21-dihydroxy-4-pregnene-3,20-dione 
• 80134-08-3 21-Brom-17-(formyloxy)-4-pregnen-3,20-dion 
• 434-03-7 levonorgestrel 
• 63973-94-4 17α-hydroxy-20-methoxypregna-4,20-diene-3-one 
• 152-58-9 Cortexolone 
• 107222-65-1 17α-(Bromethinyl)-17β-(trichloracetoxy)-4-androsten-3-on 
• 95716-48-6 17α-(Bromethinyl)-17β-(trifluoracetoxy)-4-androsten-3-on 
• 107222-62-8 17α-Ethinyl-17β-(trichloracetoxy)-4-androsten-3-on 
• 95716-47-5 17α-(Bromethinyl)-17β-(nitrooxy)-4-androsten-3-on 
• 65851-76-5 17α-ethynyl-17β-nitro-oxy-4-androsten-3-one 
• 85639-42-5 17α-ethynyl-17β-trifluoroacetoxy-androst-4-en-3-one 
• 387-79-1 17-Hydroxypregnenolone 
• 2827-40-9 21-bromo-3β,17α-dihydroxy-5-pregnen-20-one 
• 132950-03-9 17α-hydroxy-3-(N-morpholinyl)pregna-3,5-dien-20-one 

Downstream Products

• 114967-87-2 β-(17α-Hydroxy-4-pregnene-3,20-dion-21-yl-21-thio)propionic acid 
• 434-03-7 levonorgestrel 
• 640-87-9 cortexolone 21-acetate 
• 114967-86-1 α-(17α-Hydroxy-4-pregnene-3,20-dion-21-yl-21-thio)propionic acid 
• 152-58-9 Cortexolone 

Relevant articles and documents

Efficient Synthesis of the Corticosteroid Side-chain from 17-Ketones

Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphonate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

Process for the preparation of 21-bromo-4-pregnene-3,20-dione derivatives

A process is disclosed for the preparation of 21-bromo-4-pregnene-3,20-dione derivatives of general Formula I STR1 wherein R1 is a hydrogen atom, a hydroxy group or an alkanoyl group of up to 6 carbon atoms, R2 symbolizes a hydrogen atom or a methyl group, or wherein R1 and R2 jointly mean an isopropylidenedioxy group, wherein R3 is a hydrogen atom, a fluorine atom or a methyl group, V is a methylene group or ethylene group, X is a hydrogen atom, a fluorine atom or a chlorine atom, and Y is a methylene group, a hydroxymethylene group or a carbonyl group.

SYNTHESIS OF THE 21-ACETATE OF SUBSTANCE S FROM 17α-HYDROXYPROGESTERONE

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