Efficient Synthesis of the Corticosteroid Side-chain from 17-Ketones

DOI: 10.1039/c39810000774

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 774 - 775 (1981)

Update date:2022-08-17

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Authors:

Barton, Derek H. R.

Motherwell, William B.

Zard, Samir Z.

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Article abstract of DOI:10.1039/c39810000774

Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphonate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

Full text of DOI:10.1039/c39810000774

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