17531-59-8Relevant articles and documents
Synthesis, characterization and physiochemical information, along with antimicrobial studies of some metal complexes derived from an ON donor semicarbazone ligand
Siji,Kumar, M.R. Sudarsana,Suma,Kurup, M.R. Prathapachandra
, p. 22 - 28 (2010)
Eight new transition metal complexes of benzaldehyde-N(4)-phenylsemicarbazone have been synthesized and characterized by elemental analyses, molar conductance, electronic and infrared spectral studies. In all the complexes, the semicarbazone is coordinate
Microwave-assisted Synthesis and Bioevaluation of Some Semicarbazones
Jafri, Laila,Ansari, Farzana L.,Jamil, Maryam,Kalsoom, Saima,Qureishi, Sana,Mirza, Bushra
experimental part, p. 950 - 959 (2012/08/28)
In continuation to our efforts in finding potential therapeutic agents, a variety of biologically significant semicarbazones were synthesized by the reaction of different carbonyl compounds with phenyl semicarbazides through microwave irradiation. Initial
Structural modifications of the primary amino group of anticonvulsant aryl semicarbazones
Dimmock,Puthucode,Lo,Quail,Yang,Stables
, p. 83 - 88 (2007/10/02)
A number of aryl semicarbazones had been shown previously to possess significant anticonvulsant properties. The principal objective of the present investigation was to determine the importance of the primary amino group in this series of compounds by replacing it with other substituents. The results indicate that the amino group was not essential for anticonvulsant activity. However its replacement by an aryl ring generally abolished activity while a terminal phenylamino function was better tolerated. Thus both the size of the group and its hydrogen bonding capabilities appear to influence bioactivity. Alteration of the oxygen atom of the semicarbazones by isosteres did not enhance anticonvulsant properties.
