20411-76-1

Upstream product

• 60-29-7 diethyl ether 
• 36678-63-4 ethoxyethynylmagnesium bromide 
• 67-64-1 acetone 
• 927-80-0 1-ethoxyacetylene 
• 42345-82-4 (E)-1,2-dichloro-1-ethoxy-ethene 
• 621-62-5 chloroacetaldehyde diethyl acetal 

Downstream Products

• 100052-49-1 2-cyclohexylmercapto-3-methyl-crotonaldehyde 
• 100970-91-0 3-methyl-2-propylsulfanyl-crotonaldehyde-(2,4-dinitro-phenylhydrazone) 
• 18267-36-2 ethyl 3-hydroxy-3-methylbutanoate 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 638-10-8 ethyl 3-methylbut-2-enoate 
• 89005-38-9 3-methyl-2-phenylsulfanylbut-2-enal 
• 99853-18-6 2-(4-bromo-phenylsulfanyl)-3-methyl-crotonaldehyde 
• 103212-42-6 2-benzylsulfanyl-3-methyl-crotonaldehyde dibenzyldithioacetal 
• 99853-93-7 2-(4-chloro-phenylsulfanyl)-3-methyl-crotonaldehyde 
• 101498-57-1 2-(4-tert-butyl-phenylsulfanyl)-3-methyl-crotonaldehyde 
• 541-47-9 3-Methylbutenoic acid 
• 13209-80-8 N-phenyl-3-methyl-2-butenamide 
• 109729-85-3 N-(4-methoxyphenyl)-3-methyl-2-butenamide 
• 99985-75-8 β-hydroxy-isovaleric acid anilide 

Relevant academic research and scientific papers

Alkoxyacetylenes from alkyl 1,2-dichlorovinyl ethers

Alkyl 1,2-dichlorovinyl ethers 4, prepared from sodium alkoxides 1 and trichloroethylene 2, react in tetrahydrofuran with two equivalents of butyllithium to afford lithium alkoxyacetylides 5. On the one hand, these acetylides react with ketones or dichlor

A Simple, One-Pot Synthesis of 1-Alkoxy-1-alkynes and 1-Alkoxy-1-alkyn-3-ols

The title compound are prepared by a high yield, one-pot reaction using readily available chloroacetaldehyde dialkyl acetals as starting materials.The reaction is initiated by sodium amide and the intermediate acetylide anion thus produced, reacts readily with a variety of electrophiles such as alkyl halides, carbonyl compounds or water to produce the desired products.