20485-38-5Relevant articles and documents
Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes
Hidalgo-Figueroa, Sergio,Rodríguez-Luévano, Ana,Almanza-Pérez, Julio C.,Giacoman-Martínez, Abraham,Ortiz-Andrade, Rolffy,León-Rivera, Ismael,Navarrete-Vázquez, Gabriel
, (2021/06/18)
The current manuscript describes two molecules that were designed against PPARγ and GPR40 receptors. The preparation of the compounds was carried out following a synthetic route of multiple steps. Then, the mRNA expression levels of PPARγ, GLUT4, and GPR4
GK and PPAR dual agonist activity aryl urea derivatives
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, (2016/12/01)
The invention discloses a novel arylurea derivative, its preparation method, pharmaceutical composition and application. Specifically, the invention relates to an arylurea derivative as shown in the general formula I, its medicinal salt, a preparation met
2,4-Pyrimidinediamine Compounds and Their Uses
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, (2015/11/10)
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.