19786-48-2Relevant articles and documents
Rapid and high-yield synthesis of aryloxyacetates under microwave irradiation and phase-transfer catalysis conditions
Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
, p. 1759 - 1764 (2005)
A series of methyl aryloxyacetates (3a-3f) have been synthesized by the reaction of substituted phenol with methyl chloroacetate under the conditions of microwave irradiation and phase-transfer catalysis. By the optimization of the reaction conditions, we developed a good method for the preparation of methyl aryloxyacetates, which have the advantages of high yields, short reaction times, ease of workup, and simple operation. Copyright Taylor & Francis, Inc.
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core
Liosi, Maria-Elena,Krimmer, Stefan G.,Newton, Ana S.,Dawson, Thomas K.,Puleo, David E.,Cutrona, Kara J.,Suzuki, Yoshihisa,Schlessinger, Joseph,Jorgensen, William L.
, p. 5324 - 5340 (2020/06/10)
Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential components of the JAK-STAT signaling pathway. Associated aberrant signaling is responsible for many forms of cancer and disorders of the immune system. The present focus is on the d
New: N -phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors
Zidar, Nace,Macut, Helena,Toma?i?, Tihomir,Peterlin Ma?i?, Lucija,Ila?, Janez,Zega, Anamarija,Tammela, P?ivi,Kikelj, Danijel
supporting information, p. 1007 - 1017 (2019/06/27)
Due to the rapid development of antimicrobial resistance, the discovery of new antibacterials is essential in the fight against potentially lethal infections. The DNA gyrase B (GyrB) subunit of bacterial DNA gyrase is an excellent target for the design of