504-88-1 Usage
Chemical Properties
gold crystalline solid
Uses
Different sources of media describe the Uses of 504-88-1 differently. You can refer to the following data:
1. antineoplastic
2. 3-Nitropropionic acid has been used:to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic graftsto inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine systemas succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines
General Description
Golden crystals (from chloroform).
Air & Water Reactions
Water soluble.
Reactivity Profile
3-NITROPROPIONIC ACID is incompatible with bases, oxidizing agents and reducing agents.
Fire Hazard
Flash point data for 3-NITROPROPIONIC ACID are not available; however, 3-NITROPROPIONIC ACID is probably combustible.
Biological Activity
3-nitropropionic acid is an irreversible inhibitor of mitochondrial respiratory complex ii (succinate dehydrogenase), which impairs cellular energy metabolism by inhibiting succinate dehydrogenase and reducing atp production. also, 3-nitropropionic acid can cause the generation and release of reactive oxygen species (ros) from mitochondria (the main source of cellular oxidative stress), mitochondrial dna damage, as well as loss of mitochondrial function.1. huang ls, sun g, cobessi d, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex ii, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. journal of biological chemistry, 2006, 281(9): 5965-5972.2. zhang jq, shen m, zhu cc, et al. 3-nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse. plos one, 2014, 9(2): e86589.3. mandavilli bs, boldogh i, van houten b. 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial dna damage, and cell death are attenuated by bcl-2 overexpression in pc12 cells. brain research. molecular brain research, 2005, 133(2): 215-223.
Biochem/physiol Actions
Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
Safety Profile
Poison by intravenous andintraperitoneal routes. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.
Check Digit Verification of cas no
The CAS Registry Mumber 504-88-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 504-88:
(5*5)+(4*0)+(3*4)+(2*8)+(1*8)=61
61 % 10 = 1
So 504-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)/p-1
504-88-1Relevant articles and documents
Oxidative cleavage of lactams in water using dioxiranes: An expedient and environmentally-safe route to ω-nitro acids
Annese, Cosimo,D'Accolti, Lucia,Filardi, Rosella,Tommasi, Immacolata,Fusco, Caterina
, p. 515 - 517 (2013/02/23)
By taking advantage of the appreciable stability of dioxiranes in water, a safe yet efficient route to ω-nitro acids by oxidation of lactams of various ring sizes under mild conditions has been reported. In essentially all the cases examined, reactions proceed selectively to afford products in remarkably high yields (up to 99%) and with high purity (94-99%). Also, an interesting example of higher reaction selectivity in water than in organic solvent (acetonitrile) is discussed.
NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF
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Page/Page column 45-46, (2012/07/14)
The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem- loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.
