204989-01-5

Upstream product

• 204988-85-2 4-(4-Methoxy-phenyl)-5-oxo-2-thioxo-2,5-dihydro-1H-indeno[1,2-b]pyridine-3-carbonitrile 
• 79-07-2 Chloroacetamide 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 7421-76-3 2-(4-methoxybenzylidene)indane-1,3-dione 
• 39145-31-8 2-cyano-3-(4-methoxyphenyl)thioacrylamide 

Downstream Products

• 204989-13-9 1-Amino-10-(4-methoxy-phenyl)-9-oxo-9H-3-thia-4-aza-cyclopenta[b]fluorene-2-carboxylic acid amide 
• 204989-18-4 5-(4-Methoxy-phenyl)-3-thioxo-3,4-dihydro-2H-12-thia-2,4,11-triaza-indeno[1,2-b]fluorene-1,6-dione 

Relevant academic research and scientific papers

Synthesis of Indenopyridines and Indenothienopyridines

4-Aryl-3-cyano-5-oxo or (phenylimino)indenopyridin-2thiones 3a-c were prepared from indanone 1 with arylidene cyanothioacetamide or from arylideneindanone 2 with cyanothioacetamide.The corresponding 2-aminoindenopyridine 4 was synthesized from the reaction of 3b with NaN3 in the presence of NH4Cl in DMF.Hydrolysis of 4 using NaOH or H2SO4 gave compounds 6 and 7, respectively.S-Alkylation of 3 with halo compounds afforded derivatives 9a-p, which underwent ring closure with EtONa to produce indenothienopyridines 10a-1.