2050-76-2

Basic information

• Product Name: 2,4-DICHLORO-1-NAPHTHOL
• Synonyms: 2,4-DICHLORONAPHTHOL;2,4-DICHLORO-1-NAPHTHOL 99%;2,4-Dichloro-1-naphthol [for photography];2,4-Dichloronaphthalen-1-ol;2,4-Dichloro-1-naphthol,99%;[for photography];2,4-Dichloro-1-naphthol AURORA KA-5007
• CAS NO: 2050-76-2
• Molecular Formula: C₁₀H₆Cl₂O
• Molecular Weight: 213.06
• EINECS: 218-103-6
• Product Categories: Industrial/Fine Chemicals;Aromatic Halides (substituted);Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 2050-76-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 104-107 °C(lit.)
• Boiling Point: 305.89°C (rough estimate)
• Flash Point: 134 °C
• Appearance: off-white to tan/powder
• Density: 1.2937 (rough estimate)
• Vapor Density: 7.3 (vs air)
• Vapor Pressure: 4.43E-05mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: 2-8°C
• Solubility: pyridine: soluble5%, clear, colorless to dark yellow
• CAS DataBase Reference: 2,4-DICHLORO-1-NAPHTHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-1-NAPHTHOL(2050-76-2)
• EPA Substance Registry System: 2,4-DICHLORO-1-NAPHTHOL(2050-76-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 2050-76-2(Hazardous Substances Data)

Usage

Chemical Properties

beige-yellowish crystalline powder

Uses

2,4-Dichloro-1-naphthol has been used in:spectrophotometric determination of arginine with previous modifications of the Sakaguchi reactionguanidinoacetate and guanidinosuccinate assay of urine, an indicator of kidney dysfunction

Purification Methods

Crystallise the naphthol pKEst from MeOH. The 1-methyl ether has m 58o (from EtOH). [Beilstein 6 H 612, 6 I 308, 6 II 582, 6 III 2934, 6 IV 4233.]

InChI:InChI=1/C10H6Cl2O/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,13H

Upstream product

• 90-15-3 α-naphthol 
• 91-20-3 naphthalene 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 605-36-7 1,2,3,4-tetrahydro-1,2,3,4-tetrachloronaphthalene 
• 94688-65-0 4,4'-trisulfanediyl-di-[1]naphthol 
• 604-44-4 4-chloronaphthalen-1-ol 
• 17735-08-9 2,2,4-trichloro-1(2H)-naphthalenone 

Downstream Products

• 129015-48-1 2-chloro-[1,4]naphthoquinone-4-(4-dimethylamino-phenylimine) 
• 5435-74-5 acetic acid-(2,4-dichloro-[1]naphthyl ester) 
• 5466-48-8 (2,4-dichloro-[1]naphthyloxy)-acetic acid 
• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 91-20-3 naphthalene 
• 17539-31-0 ethyl α-naphthyl sulfide 
• 6655-90-9 4-chloronaphthalene-1,2-dione 
• 133546-45-9 N,N'-thiobis<3-chloro-1,4-naphthoquinone 1-imine> 
• 57234-84-1 5-Chloronaphtho<1,2-c><1,2,5>thiadiazole 
• 34910-56-0 naphtho<1,2-c:3,4-c'>bis<1,2,5>thiadiazole 
• 90-15-3 α-naphthol 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 136613-48-4 4-chloro-2-naphthonitrile 
• 136613-50-8 4-chloro-2-(p-tolylsulphonylmethyl)-1-naphthonitrile 

Relevant articles and documents

Regioselective Oxidative Chlorination of Arenols Using NaCl and Oxone

We developed a practical and environmentally benign method for the chlorinative dearomatization of arenols using transient electrophilic chlorinating species generated in situ from inexpensive sodium chloride and Oxone as a Cl source and oxidant, respectively, under mild conditions. Moreover, the regioselective chlorination or chlorinative dearomatization of 1-naphthols was also achieved by changing the reaction conditions.

N-Chloro-N-methoxybenzenesulfonamide: A Chlorinating Reagent

A structurally simple and reactive chlorinating reagent, N-chloro-N-methoxybenzenesulfonamide, was conveniently and economically prepared in high yield. 1,3-Diketones, β-keto esters, benzoyl trifluoroacetones, phenols, anisoles, heteroarenes, and aromatic amines were successfully chlorinated, and the products were obtained in good to high yields.

Imidazolylsulfonates: Electrophilic partners in cross-coupling reactions

Aryl imidazolylsulfonates participate as electrophilic coupling partners in palladium-mediated cross-coupling reactions. The aryl imidazolylsulfonates display good stability while maintaining good reactivity in a variety of palladium-catalyzed coupling reactions. Imidazolylsulfonates are a practical and economic alternative to triflates.