20531-86-6

Basic information

• Product Name: 2-benzylpyridine 1-oxide
• Synonyms: 2-Benzylpyridine 1-oxide; pyridine, 2-(phenylmethyl)-, 1-oxide
• CAS NO: 20531-86-6
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.2218
• Mol File: 20531-86-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 185.5°C
• Density: 1.04g/cm³
• Vapor Pressure: 9.93E-06mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 2-benzylpyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylpyridine 1-oxide(20531-86-6)
• EPA Substance Registry System: 2-benzylpyridine 1-oxide(20531-86-6)

Safety Data

• Hazardous Substances Data: 20531-86-6(Hazardous Substances Data)

Upstream product

• 941279-81-8 2,4-dimethyl-3-(pyridin-2-ylmethyl)pentan-3-ol 
• 109-06-8 α-picoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 694-59-7 pyridine N-oxide 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 110-86-1 pyridine 
• 108-88-3 toluene 
• 109-09-1 2-chloropyridine 
• 6921-34-2 benzylmagnesium chloride 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 108-86-1 bromobenzene 
• 1201921-86-9 C₁₃H₂₁NO₂ 

Downstream Products

• 20482-09-1 2-(4-nitro-benzyl)-pyridine-1-oxide 
• 93-98-1 N-phenyl benzoyl amide 
• 28830-48-0 α,α'-bis-(2-pyridyl)bibenzyl 
• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 40473-17-4 2‐(chloro(phenyl)methyl)pyridine 
• 76809-16-0 2,2-Dimethyl-3-(phenyl-pyridin-2-yl-methyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 76809-26-2 3-(2-Benzyl-pyridin-3-yl)-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 76809-33-1 3-(6-Benzyl-pyridin-3-yl)-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 101-82-6 2-Benzylpyridine 
• 245-43-2 benzo<2,3>indolizine 
• 57963-09-4 6-benzylpyridin-2-amine 
• 139478-84-5 6-benzylpicolinonitrile 
• 80205-36-3 [Rh(COD)(2-BzPyO)2]ClO₄ 
• 80005-91-0 [Rh(COD)(2-BzPyO)(PPh₃)]ClO₄ 

Relevant articles and documents

Synthesis of methylpyridine derivatives. XXIX. Arylation of methylpyridine and its derivatives (Japanese)

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Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigamatropic rearrangement reaction

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigamatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported.

The M?CPbA?NH3(G) system: A safe and scalable alternative for the manufacture of (substituted) pyridine and quinoline N?oxides?

An improved, safe, and scalable isolation process for (substituted) pyridine and quinoline N-oxides in quantitative yields along with high purities using the m-CPBA?NH3(g) system is described. The safety was assessed by reaction calorimetry and differential scanning calorimetry studies for possible hazards during the conversion and isolation steps. Careful interpretation of the data substantiated the safety and scalability. The process flow is simplified to meet the industrial requirements of safety, cost-effectiveness, and utility minimization. The reaction was safely demonstrated at a 2.5 kg scale.