40473-17-4

Upstream product

• 20531-86-6 2-benzylpyridine-N-oxide 
• 74405-07-5 4-chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine 
• 31796-72-2 phenyl(2-pyridinyl)methanol 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 110-86-1 pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 100-52-7 benzaldehyde 

Downstream Products

• 90672-61-0 1-methyl-4-(phenyl-[2]pyridyl-methyl)-piperazine 
• 1234804-57-9 1‐methyl‐3‐[phenyl(pyridin‐2‐yl)methyl]‐1H‐imidazolium chloride 
• 1438252-69-7 1‐phenyl‐3‐[phenyl(pyridin‐2‐yl)methyl]‐1H‐imidazolium chloride 

Relevant academic research and scientific papers

CONDENSED HETEROCYCLES WITH A THIAZOLE RING. 16. CYANINE DYES BASED ON THIAZOLOPYRIDINIUM SALTS

The reaction of 2-(α-chlorobenzyl)pyridines with thioacetamide gave 3-methyl-1-arylthiazolopyridinium salts, which form cyanines.It was established that the thiazolopyridinium ring in the dyes has high electron-donor character and a great effective

Synthesis, characterization, in vitro antimicrobial and anticancer studies of new platinum N-heterocyclic carbene (NHC) complexes and unexpected nickel complexes

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the

Palladium complexes of bidentate pyridine N-heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

A series of bidentate pyridine-functionalized palladium N-heterocyclic carbene (Pd NHC) complexes with various wingtip substituents (R?=?methyl, phenyl and tert-butyl) have been synthesized and evaluated for their potential biomedical applications as anti

Synthesis and characterisation of a novel chiral bidentate pyridine-N-heterocyclic carbene-based palladacycle

A novel chiral six-membered bidentate pyridine-N-heterocyclic carbene palladacycle was prepared via optical resolution of the racemic palladacycle. This is the first successful demonstration of the synthesis of a chiral carbene palladacycle via fractional

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors

A series of pyrazolo[3,4-d]pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl group at the N-1 position and the hydrophobic diarylmethyl group at the piperazine largely influenced the in vitro antienteroviral activity of this new class of potent antiviral agents. It was found that the pyrazolo[3,4-d]pyrimidines with a thiophene substituent, such as compounds 20-24, in general exhibited high activity against coxsackievirus B3 (IC50=0.063-0.089μM) and moderate activity against enterovirus 71 (IC50=0.32-0.65μM) with no apparent cytotoxic effect toward RD (rhabdomyosarcoma) cell lines (CC5025μ M).

Heterocyclic Analogues of Chlorcyclizine with Potent Hypolipidemic Activity

A series of piperazines was synthesized and their effect of reducing serum cholesterol and triglyceride levels in the rat was evaluated.A systematic exploration of the structure-activity relationships led to the synthesis of (R,S)-(3,5-dimethylisoxazol-4-yl)(4-methylpiperazin-1-yl)methane dihydrochloride (M and B 31426), which had potent activity in lowering serum lipid levels at a daily oral dose of 2 mg/kg and was 100 times more potent than clofibrate.

Studies on 1,3-Benzoxazines. II. New Rearrangement Modes in the Reaction of 4-Chloro-2,2-dimethyl-2H-1,3-benzoxazine with Substituted Pyridine N-Oxides

New rearrangement modes in the reaction of 4-chloro-2,2-dimethyl-2H-1,3-benzoxazine (1) with various α- and/or γ-substituted pyridine N-oxides are described.The benzoxazine moiety was introduced into the side chain and/or β-position of the pyridine ring, in addition to the α-position.Possible mechanism of the reactions are discussed.Keywords - 1,3-benzoxazine; picoline N-oxide; lutidine N-oxide; imidoyl chloride; rearrangement.