205320-02-1

Basic information

• Product Name: 4-chloro-N,2-dimethoxy-N-methylbenzamide
• Synonyms: 4-chloro-N,2-dimethoxy-N-methylbenzamide;4-Chloro-2,N-diMethoxy-N-Methyl-benzaMide
• CAS NO: 205320-02-1
• Molecular Formula: C₁₀H₁₂ClNO₃
• Molecular Weight: 230
• EINECS: 200-589-5
• Mol File: 205320-02-1.mol

Chemical Properties

• Boiling Point: 388 °C at 760 mmHg
• Flash Point: 188.4 °C
• Appearance: /
• Density: 1.227 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-chloro-N,2-dimethoxy-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N,2-dimethoxy-N-methylbenzamide(205320-02-1)
• EPA Substance Registry System: 4-chloro-N,2-dimethoxy-N-methylbenzamide(205320-02-1)

Safety Data

• Hazardous Substances Data: 205320-02-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Chloro-N,2-dimethoxy-N-methylbenzamide is used as a synthetic intermediate for the preparation of various organic compounds. Its unique functional groups make it a valuable building block in the synthesis of complex molecules, contributing to the development of new chemical entities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Chloro-N,2-dimethoxy-N-methylbenzamide is used as a potential pharmaceutical candidate. Its structural features may allow it to interact with biological targets, such as enzymes or receptors, and could be further optimized for therapeutic applications, including the treatment of diseases or disorders.
Used in Material Science:
4-Chloro-N,2-dimethoxy-N-methylbenzamide is used as a component in the development of new materials. Its chemical properties may contribute to the creation of advanced materials with specific characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industries, including electronics, coatings, or adhesives.

Upstream product

• 57479-70-6 2-methoxy-4-chlorobenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 5607-64-7 4-chloro-2-anisoyl chloride 

Downstream Products

• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 1127-97-5 1-(4-chloro-2-hydroxy-phenyl)-propan-1-one 
• 114741-22-9 7-chloro-4-oxo-4H-chromene-2-carboxylic acid 
• 60207-19-4 1-(4-chloro-2-methoxyphenyl)-ethanone 
• 36871-55-3 4-chloro-2-methoxypropiophenone 

Relevant articles and documents

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: Assessment of potency, efficacy, and cardiovascular safety

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against the chosen cardiovascular endpoints at high drug concentrations in the plasma and brain. Optimization of this series led to considerable improvements in affinity, functional potency, and pharmacokinetic profile. This led to the identification of a 7-fluorochromone-2-carboxamide (22) that was orally efficacious in a diet-induced obese mouse model, retained a favorable cardiovascular profile in rat, and demonstrated dramatic improvement in effects on mean arterial pressure in our dog cardiovascular model compared to other series reported by our group. However, this analogue also led to prolongation of the QT interval in the dog that was linked to affinity for hERG channel and unexpectedly potent functional blockade of this ion channel.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.