205320-02-1

Basic information

• Product Name: 4-chloro-N,2-dimethoxy-N-methylbenzamide
• Synonyms: 4-chloro-N,2-dimethoxy-N-methylbenzamide;4-Chloro-2,N-diMethoxy-N-Methyl-benzaMide
• CAS NO: 205320-02-1
• Molecular Formula: C₁₀H₁₂ClNO₃
• Molecular Weight: 230
• EINECS: 200-589-5
• Mol File: 205320-02-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 388 °C at 760 mmHg
• Flash Point: 188.4 °C
• Appearance: /
• Density: 1.227 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-chloro-N,2-dimethoxy-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N,2-dimethoxy-N-methylbenzamide(205320-02-1)
• EPA Substance Registry System: 4-chloro-N,2-dimethoxy-N-methylbenzamide(205320-02-1)

Safety Data

• Hazardous Substances Data: 205320-02-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-N,2-dimethoxy-N-methylbenzamide is a chemical compound characterized by the presence of key functional groups such as chloro, amide, and methoxy groups. While there is not an extensive amount of information available on this specific compound, its structural features suggest that it is likely to be a synthetic organic compound, potentially used in various fields including organic synthesis, medicinal chemistry and material science. However, the precise properties, uses, and safety profile can vary based on its specific molecular configuration and should be referred from a verified chemical database or a safety data sheet. The compound contains carbon, hydrogen, nitrogen, oxygen, and chlorine atoms, characteristic of many organic compounds.

Upstream product

• 57479-70-6 2-methoxy-4-chlorobenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 5607-64-7 4-chloro-2-anisoyl chloride 

Downstream Products

• 36871-55-3 4-chloro-2-methoxypropiophenone 
• 60207-19-4 1-(4-chloro-2-methoxyphenyl)-ethanone 
• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 1127-97-5 1-(4-chloro-2-hydroxy-phenyl)-propan-1-one 
• 114741-22-9 7-chloro-4-oxo-4H-chromene-2-carboxylic acid 

Relevant articles and documents

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: Assessment of potency, efficacy, and cardiovascular safety

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against the chosen cardiovascular endpoints at high drug concentrations in the plasma and brain. Optimization of this series led to considerable improvements in affinity, functional potency, and pharmacokinetic profile. This led to the identification of a 7-fluorochromone-2-carboxamide (22) that was orally efficacious in a diet-induced obese mouse model, retained a favorable cardiovascular profile in rat, and demonstrated dramatic improvement in effects on mean arterial pressure in our dog cardiovascular model compared to other series reported by our group. However, this analogue also led to prolongation of the QT interval in the dog that was linked to affinity for hERG channel and unexpectedly potent functional blockade of this ion channel.