205433-74-5

Upstream product

• 100-39-0 benzyl bromide 
• 106-95-6 allyl bromide 
• 584-82-7 2-allyl-4-methoxyphenol 
• 13391-35-0 allyl (4-methoxyphenyl) ether 
• 13677-76-4 2-allyl-5-methoxyphenol 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 1177405-68-3 3-(2-benzyloxy-5-methoxyphenyl)propan-1-ol 
• 1392489-48-3 (S)-(6-benzyloxy)-2-((cyclopropylmethoxy)methyl)chroman 
• 905454-77-5 (R)-(6-benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)chroman 
• 1392489-47-2 C₁₇H₁₈O₃ 
• 1392489-46-1 (S)-1-((R)-6-benzyloxychroman-2-yl)ethane-1,2-diol 
• 1132981-64-6 3-(2-(benzyloxy)-5-methoxyphenyl)propanal 
• 205433-76-7 2-(2-benzyloxy-5-methoxybenzyl)-1,3-dioxolane 
• 141988-89-8 2-(1,3-dioxolan-2-ylmethyl)-4,4-dimethoxy-2,5-cyclohexadienone 
• 141989-04-0 2-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenol 
• 205433-75-6 2-(2-benzyloxy-5-methoxyphenyl)acetaldehyde 
• 391687-85-7 2-(2,2-dimethoxyethyl)-α-(2-phenylmethoxy-5-methoxyphenylmethyl)benzenemethanol 
• 391687-87-9 3,4-dihydro-3-methoxy-1-(2-phenylmethoxy-5-methoxyphenylmethyl)-1H-2-benzopyran 
• 391687-89-1 5,6,11,12-tetrahydro-4-methoxy-1-phenylmethoxy-5,11-epoxydibenzo[a,c]cyclooctene 

Relevant academic research and scientific papers

Base-mediated synthesis of benzimidazole-fused 1,4-benzoxazepines via sequential intermolecular epoxide ring-opening/intramolecular SNAr reactions

We have developed a transition-metal-free, practical route to benzimidazole-fused 1,4-benzoxazepines. Operationally, the protocol involves a K2CO3-mediated intermolecular ring opening of terminal epoxides by 2-(2-fluorophenyl)benzimi

NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE

A compound of Formula (I), and its pharmaceutically acceptable salt or salts and physiologically hydrolysable derivatives in free form or salt form: wherein R1 is independently selected from F, CI, Br, CN, NH2, OH, CHO, COOH, oxo, C1-4alkyl, C1-4alkoxy, CONH2 (optionally mono- or di-substituted by C1-4alkyl) and SO2NH2, R2 is independently selected from C1-6allkyl substituted by R3 wherein the C1-6alkyl chain optionally comprises one or two heteroatoms select from O; R3 is selected from aryl, C3-6cycloalkyl, C3-6heterocyclyl and C3-6heteroaryl, wherein the heterocyclyl and heteroaryl rings are nitrogen containing; and wherein R3 is optonally substituted by one or more groups selected from R1; n1 is zero or an integer from 1 to 2; n2 is an integer from 1 to 2; and the sum of n1 and 2 is less than or equal to 2; R5 is selected from any group defined for R1 and R2; R6a and R6b are independently selected from H or C1-4alkyl; R7 is independently selected from F, CI, Br, CN, NH2, OH, CHO, COOH, oxo, C1-4alkyl, C1-4alkoxy, CONH2 (optionally mono- or di-substituted by C1-4alkyl) and SO2NH2, Q1, Q2 and Q3 are independently selected from H or any group defined for R1 and R2; or Q1 and Q2 or Q2 and Q3 together form a C5-6heteroaryl or C5-6heterocylclic ring; optionally containing one or two heteroatoms selected from N and O optionally substituted by any group selected from R5; Z is selected from linear C2-3 alkylene; X3 is O; X4 is selected from aryl, a 9-10 membered heteroaryl ring or a 9-10 membered heterocyclic ring, wherein the heteroaryl and heterocyclic rings contain one or more heteroatoms selected from N, and optionally additionally O, and wherein X4 is optionally substituted by one or two oxo moieties and is optionally substituted by one or more groups selected from R7; with the proviso that: (i) when X4 is phenyl then Q1 and Q2 or Q2 and Q3-together form an optionally substituted heteroaryl or heterocylclic ring as defined above; and (ii) when Q1, Q2 and Q3 are independently selected from H or any group defined for R1 and R2 then X4 is not phenyl except when R2 is C1-5alkyl substituted by R3 wherein R3 is C3-6heterocyclyl as defined above.

Application of phenolate ion mediated intramolecular epoxide ring opening in the enantioselective synthesis of functionalized 2,3-dihydrobenzofurans and 1-benzopyrans

The enantioselective synthesis of 2-isopropenyl-2,3-dihydrobenzofurans, 4-(2,3-dihydrobenzofuran-2-yl)-2-methylbut-3-en-2-ols, 2-hydroxymethyl chromans, and 4-chroman-2-yl-2-methylbut-3-en-2-ols has been achieved using Sharpless asymmetric epoxidation-der

The preparation of chiral salicylaldehydes based on Kagan's ether

Two related routes to chiral salicylaldehydes which are derivatives of Kagan's ether have been developed. One route which is particularly simple begins with 2,6-diallylphenol. Facile conversion to a substituted benzofuran and assemblage of the basic framework of Kagan's ether is followed by an ozonolysis of the benzofuran ring to reveal the hydroxyaldehyde functionality characteristic of salicylaldehydes.

Photochemistry of Substituted 4,4-Dimethoxy-2,5-Cyclohexadienones

4,4-Dimethoxy-2,5-cyclohexadienones 9-14 were prepared from the corresponding hydroquinone monomethyl ethers by oxidation with thallium trinitrate in methanol. Irradiation of solutions of 9-13 in methanol with a broad band of UV light centered at 350 nm in a Rayonet reactor afforded 2-cyclopentenone derivatives 15-19 in moderate to excellent yields, whereas irradiation of 14 in methanol gave phenol 8 along with other unidentified products. Irradiation of 11-14 in benzene yielded substituted phenols. The plausible reaction pathways for the product formation are discussed.