205448-29-9

Basic information

• Product Name: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone
• Synonyms: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone;7-Benzyloxy-6-methoxy-1H-quinolin-4-one;7-(benzyloxy)-6-Methoxyquinolin-4(1H)-one;7-(Benzyloxy)-6-methoxy-4(1H)-quinolinone
• CAS NO: 205448-29-9
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.31
• Mol File: 205448-29-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 460.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.218
• PKA: 2.71±0.50(Predicted)
• CAS DataBase Reference: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone(205448-29-9)
• EPA Substance Registry System: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone(205448-29-9)

Safety Data

• Hazardous Substances Data: 205448-29-9(Hazardous Substances Data)

Usage

Description

7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone is a quinolinone derivative with the molecular formula C20H19NO3. It features a benzyl and a methoxy group attached to its structure, endowing it with potential pharmacological properties. This chemical compound is of interest in the fields of organic and medicinal chemistry, and it may serve as a building block in the synthesis of various pharmaceutical compounds due to its unique structure and properties.

Uses

Used in Medicinal Chemistry:
7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its presence in the molecular structure can contribute to the development of new drugs with specific therapeutic effects.
Used in Drug Development:
In the pharmaceutical industry, 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone is used as a potential candidate for drug development. Its pharmacological properties are being studied to explore its efficacy in treating various diseases and conditions.
Used in Organic Chemistry Research:
7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone is used as a subject of research in organic chemistry to understand its reactivity, synthesis pathways, and potential applications in the creation of novel organic compounds.
Used in Synthesis of Bioactive Molecules:
Due to its unique structure, 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone is used as a precursor in the synthesis of bioactive molecules. Its incorporation into complex organic molecules can enhance their biological activity, making it a valuable component in the development of new therapeutic agents.

Upstream product

• 100-39-0 benzyl bromide 
• 1835-11-6 4-benzyloxy-3-methoxyacetophenone 
• 75665-88-2 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 75665-73-5 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone 
• 107-31-3 Methyl formate 
• 61324-40-1 3-benzyloxy-4-methoxybenzeneamine 
• 109-94-4 formic acid ethyl ester 
• 205448-28-8 5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione 

Downstream Products

• 205448-30-2 7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride 
• 914490-22-5 7-benzyloxy-3-bromo-6-methoxy-1H-quinolin-4-one 
• 479690-03-4 7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methyloxyquinoline 
• 479690-08-9 1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline 
• 417725-03-2 7-(benzyloxy)-6-methoxy-4-(4-nitrophenoxy)quinoline 
• 1355031-15-0 4-(4-aminophenoxy)-6-methoxyquinolin-7-ol 
• 1394821-14-7 N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394820-93-9 N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 861881-04-1 4-chloro-7-(3-chloropropoxy)-6-methoxyquinoline 
• 1622396-60-4 C₂₆H₃₀ClN₃O₄ 
• 1622396-74-0 C₂₄H₂₀FN₃O₄ 
• 1622396-75-1 C₃₀H₂₉ClFN₃O₆ 
• 1622396-76-2 C₃₀H₃₀FN₃O₆ 
• 1622396-77-3 C₂₈H₂₅ClFN₃O₆ 

Relevant articles and documents

Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate

A series of 1,6-naphthyridinone-based MET kinase inhibitors bearing quinoline moiety in block A were designed and synthesized based on the structures of Cabozantinib and our reported compound IV. Extensive SAR and DMPK studies led to the identification of 20j, a potent and orally bioavailable MET kinase inhibitor with favorable kinase selectivity. More importantly, 20j exhibited statistically significant tumor growth inhibition (Tumor growth inhibition/TGI of 131%, 4/6 partial regression/PR) in the U-87 MG xeograft model, which is superior to that of Cabozantinib (TGI of 97%, 2/6 PR), and significantly better than that of compound IV (TGI of 15%, 0/6 PR) at the same dose (12.5 mg/kg). Combined with favorable in vitro potency, kinase selectivity, pharmacokinetic profile and in vivo efficacy, the promising antitumor drug candidate 20j has subsequently advanced into preclinical research.

CARBAMATE AND UREA COMPOUNDS AS MULTIKINASE INHIBITORS

The present disclosure describes carbamate and urea compounds as novel multikinase inhibitors and methods for preparing them. The pharmaceutical compositions comprising such multikinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders associated with kinases are also described.

A alkyne generation quinoline derivatives and its preparation and use

The invention discloses alkynylquinoline derivatives, and a preparation method and application thereof. The acetylenoquinoline derivatives are alkynylquinoline compounds as shown in a general formula I which is described in the specification and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof. The invention also provides the preparation method for the derivatives and relates to inhibition activity of the compounds as shown in the formula I to a variety of protein tyrosine kinases (e.g. C-Met and VEGFR). Thus, the compounds can be used as anticancer drugs for treatment of human cancers.