20574-25-8

Upstream product

• 105691-63-2 {Pt(NH₃)I₂}2 
• 26035-31-4 cisplatine 
• 15022-60-3 NH₄{PtaCl₃}*H₂O 
• 92206-38-7 ammonium acetate 
• 10025-99-7 potassium tetrachloroplatinate(II) 
• 7664-41-7 ammonia 

Downstream Products

• 7440-06-4 platinum 
• 181630-15-9 cis-amminedichlorido(2-methylpyridine)platinum(II) 

Relevant academic research and scientific papers

A novel characterization of the structure of 'Cossa's salt' Kx(NH4)1-x[PtCl3NH3] · H2O by crystallographic comparison with the stoichiometric compounds K[PtCl3NH3] · H2O and NH4 [PtCl3NH3] · H2O

The present understanding of 'Cossa's salt' with two crystalline forms in single crystals, which describes the yellow parts of the crystal as the pure compound K[PtCl3NH3] · H2O and the red parts as K[PtCl3NH3]1-ω[PtCl5NH 3]ω (0 A more obvious explanation is that 'Cossa's salt' forms mixed-occupancy crystalline material Kx(NH4)1-x[PtCl3NH3] · H2O containing mixed counter ions with different composition of the K+ and NH4+ ions. A sample of the 'red' form with x ≈ 0.25 (2) and the 'yellow' form with x ≈ 0.75 (3) are compared with the stoichiometric compounds NH4[PtCl3NH3] · H2O, (1) published earlier, and K[PtCl3NH3] · H2O (4). The unit cell volumes decrease with increasing concentration of K+ ion, being 825.2(3) A3 for (1), 813(1) A3 for (2), 786.6(8) A3 for (3), and 774.2(8) A3 for (4).

IMPROVEMENTS IN PLATINUM COMPOUNDS PREPARATION BY USE OF TETRABUTYLAMMOUNIUM AMMINETRICHLOROPLATINATE AS INTERMEDIATE

The invention provides a commercially practicable route to X[PtCl 3 (NH 3 )], where X represents an alkali metal ion, comprising the steps of heating a reaction mixture comprising cisplatin in an acidified organic solvent, together with NBu 4 OH, a Pt catalyst and saturated aqueous NaC1 solution to form (NBu 4 )[PtCl 3 (NH 3 )], and reacting that product with an alkali metal salt, to form X[PtCl 3 (NH 3 )] The product may be used in the synthesis of platinum anticancer complexes.