205748-19-2Relevant academic research and scientific papers
Dynamic kinetic resolution (DKR) using immobilized amine nucleophiles
Valenrod, Yevgeny,Myung, Jinnie,Ben, Robert N.
, p. 2545 - 2549 (2004)
The first example of a dynamic kinetic resolution (DKR) using immobilized amine nucleophiles is described. This approach utilizes a nucleophilic amine attached to a solid phase resin via an organic spacer. The optical purities of the N-substituted α-amino ester products are superior to the solution phase DKR with diastereomeric ratios ranging from 11:1 to 18:1 and chemical yields between 66% and 98%.
Synthesis of optically active α-amino esters via dynamic kinetic resolution: A mechanistic study
Ben, Robert,Durst, Tony
, p. 7700 - 7706 (2007/10/03)
Synthesis of N-protected optically active α-amino esters from racemic α-halo esters via dynamic kinetic resolution (DKR) will be described. This methodology is general in nature and provides the desired optically active N- protected amino esters in 70-95% yield with diastereomeric excesses in the range of 85 to >98%. Applications and mechanistic aspects will be discussed.
