205756-24-7

Usage

Uses

Used in Organic Synthesis:
4-Chloro-2-trifluoroacetyl-6-(tert-butyldimethylsilyloxy)aniline is used as a synthetic intermediate for the development of various organic compounds. Its specific chemical structure allows it to be a valuable building block in the creation of complex molecules, contributing to the advancement of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-chloro-2-trifluoroacetyl-6-(tert-butyldimethylsilyloxy)aniline is used as a key component in the synthesis of certain drugs. Its unique properties enable the development of new medications with potential therapeutic applications.
Used in Chemical Research:
4-Chloro-2-trifluoroacetyl-6-(tert-butyldimethylsilyloxy)aniline is also employed in chemical research, where it serves as a model compound for studying various reaction mechanisms and exploring new synthetic pathways. This contributes to the broader understanding of organic chemistry and the development of innovative chemical processes.

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 205756-23-6 2'-amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone 
• 288-32-4 1H-imidazole 
• 205756-22-5 2'-amino-5'-chloro-3'-methoxy-2,2,2-trifluoroacetophenone 
• 113137-29-4 N-(4-chloro-2-methoxyphenyl)-2,2-dimethylpropanamide 
• 93-50-5 4-chloro-o-anisidine 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 

Downstream Products

• 205756-25-8 2-(2-Amino-5-chloro-3-(t-butyldimethylsilyloxy)-phenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol 
• 1027042-31-4 8-(tert-butyl-dimethyl-silanyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 205754-32-1 6-chloro-4-cyclopropylethynyl-8-hydroxy-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 205754-33-2 8-Hydroxyefavirenz 

Relevant academic research and scientific papers

4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME

The present invention relates to benzoxazinones of formula I, or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz

Studies on the biotransformation of the clinically important non-nucleoside reverse transcriptase inhibitor efavirenz have shown that oxidation and secondary conjugation are important components of the processing of this molecule in vivo. We have synthesized metabolites of efavirenz to confirm their structure and to evaluate their activity as antivirals.

4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same

The present invention relates to benzoxazinones of formula I: STR1 or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.