20588-32-3Relevant academic research and scientific papers
AROMATIC SULPHONAMIDES DERIVATIVES THAT INHIBITS PDI A1, THEIR SYNTHESIS AND USE
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Page/Page column 8-9; 14, (2021/07/17)
The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors
Palladium(II) mediated aziridination of olefins with bromamine-T as the nitrogen source: scope and mechanism
Antunes, Alexandra M.M.,Bonifácio, Vasco D.B.,Nascimento, Susana C.C.,Lobo, Ana M.,Branco, Paula S.,Prabhakar, Sundaresan
, p. 7009 - 7017 (2008/02/05)
The palladium(II)-promoted reaction of a variety of olefins and bromamine-T provided N-tosyl-2-substituted aziridines under mild conditions. Olefins bearing chiral appendages gave only a poor to modest diastereoselectivity. Appropriate deuterated olefins
Synthesis of Functionalized N-Arylsulfonyl Aziridines from α,β-Unsaturated Esters, Amides, Ketones, and Nitriles Using N,N-Dichloroarylsulfonamides as Nitrogen Source
Nadir, Upender K.,Singh, Anamika
, p. 1337 - 1347 (2007/10/03)
A convenient and general aziridination process has been developed for the synthesis of functionalized N-arylsulfonylaziridines bearing an alkoxycarbonyl, acyl, cyano, and carboxamide group at C2. The two-step sequence involves addition of N,N-dichloroarylsulfonamide to the appropriate olefin in the presence of Cu(acac)2, treatment of the resultant chlorosulfonamide with Na2SO3, followed by cyclization with NaOH to give the appropriate aziridine in good yields. The reaction is found to be an anti-stereoselective.
Palladium(II)-promoted aziridination of olefins with bromamine T as the nitrogen transfer reagent
Antunes,Marto,Branco,Prabhakar,Lobo
, p. 405 - 406 (2007/10/03)
The palladium(II)-promoted reaction of a variety of olefins and bromamine T, as the nitrogen atom transfer reagent, provided N-tosyl-2-substituted aziridines under mild conditions.
A new approach for the transformation of alkenes to pyrrolines via aziridine intermediates
Ajay Kumar,Lokanatha Rai,Umesha
, p. 6993 - 6996 (2007/10/03)
Alkenes (1) reacts with chloramine-T in presence of the catalyst silver nitrate to afford aziridines (2). The aziridines underwent ring expansion with the acrylo nitrile or ethyl acrylate (3) in the presence of solid sodium hydroxide to form pyrrolines (4) in 40-58% yield.
Application of the Evans aziridination procedure to 2-substituted acrylates and cinnamates: An expedient route to α-substituted α- and β- amino acids
Dauban, Philippe,Dodd, Robert H.
, p. 5739 - 5742 (2007/10/03)
Reaction of the title compounds with PhI = NSO2Ar (Ar = p-tolyl or p- nitrophenyl) in the presence of catalytic copper (II) triflate in acetonitrile gave the corresponding 2 and/or 3-substituted aziridine-2- carboxylates in generally good yield
