205999-75-3

Upstream product

• 100-39-0 benzyl bromide 
• 205999-74-2 4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine 
• 119193-19-0 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 205999-81-1 (+)-(3R,4R)-4-(3-(benzyloxy)phenyl)-3,4-dimethylpiperidine 
• 205999-77-5 3-[(3R,4R)-4-(3-Benzyloxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-1-phenyl-cyclohexanol 

Relevant academic research and scientific papers

NOVEL OPIOID ANTAGONISTS

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Investigation of the N-substituent conformation governing potency and μ receptor subtype-selectivity in (+)-(3R,4R)-dimethyl-4-(3- hydroxyphenyl)piperidine opioid antagonists

A study of the binding site requirements associated with the N- substituent of (+)-(3R,4R)dimethyl-4-(3-hydroxyphenyl)piperidine (4) derivatives was undertaken using a set of rigid vs flexible N-substituents. The study showed that compounds 7-9 bearing th