2060-55-1

Usage

Uses

Used in Pharmaceutical Industry:
2,2'-BITHIOPHENE-5-CARBOXYLIC ACID is used as a pharmaceutical intermediate for its biological activity, contributing to the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
2,2'-BITHIOPHENE-5-CARBOXYLIC ACID is used as a synthetic intermediate in organic reactions, facilitating the synthesis of complex organic molecules and compounds.
Used in Polymer Production:
2,2'-BITHIOPHENE-5-CARBOXYLIC ACID is used as a monomer or building block in the production of polymers, which are essential in various industries, including plastics, textiles, and coatings.
Used in Optoelectronic Materials:
2,2'-BITHIOPHENE-5-CARBOXYLIC ACID is used in the development of optoelectronic materials, such as organic light-emitting diodes (OLEDs) and photovoltaic cells, due to its electronic properties and potential for molecular engineering.

Upstream product

• 116016-58-1 (2Z,4E)-2-((1Z,3E)-1-Carboxy-4-thiophen-2-yl-buta-1,3-dienyldisulfanyl)-5-thiophen-2-yl-penta-2,4-dienoic acid 
• 18494-74-1 2-methyl-2,5'-bithiophene 
• 3779-27-9 2,2'-bithiophene-5-carboxaldehyde 
• 124-38-9 carbon dioxide 
• 492-97-7 2,2'-Bithiophene 
• 98-03-3 thiophene-2-carbaldehyde 
• 39511-07-4 (E)-2-(2-thienyl)ethylene-1-carbaldehyde 
• 3515-34-2 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid 
• 3515-18-2 5-acetyl-2,2'-bithiophene 
• 116016-39-8 5-<3-(2-thienyl)acrylidene>rhodanine 
• 116016-51-4 2-mercapto-5-(2-thienyl)-2,4-pentadienoic acid 

Downstream Products

• 204701-12-2 [2,2']Bithiophenyl-5-carboxylic acid benzyl ester 
• 561023-78-7 C₂₆H₁₈O₄S₄ 
• 333793-28-5 N-[3-(2,3-dimethyl-3H-imidazol-4-yl)-phenyl]-[2,2']bithiophenyl-5-carboxamide 
• 871813-49-9 trans-(tungsten)2(2,4,6-triisopropylbenzoate)2(OOC(2,4-thiophene)2H) 
• 871813-46-6 trans-(molybdenum)2(2,4,6-triisopropylbenzoate)2(OOC(2,4-thiophene)2H) 
• 215605-49-5 5'''''''-Bromo-4'',4'''''-dioctyl-[2,2';5',2'';5'',2''';5''',2'''';5'''',2''''';5''''',2'''''';5'''''',2''''''']octithiophene-5-carboxylic acid benzyl ester 
• 204701-18-8 4'',4'''''-Dioctyl-[2,2';5',2'';5'',2''';5''',2'''';5'''',2''''';5''''',2'''''';5'''''',2''''''']octithiophene-5-carboxylic acid benzyl ester 
• 215605-48-4 5'''''-Bromo-4'',4'''''-dioctyl-[2,2';5',2'';5'',2''';5''',2'''';5'''',2''''']sexithiophene-5-carboxylic acid benzyl ester 
• 204701-17-7 4'',4'''''-Dioctyl-[2,2';5',2'';5'',2''';5''',2'''';5'''',2''''']sexithiophene-5-carboxylic acid benzyl ester 
• 288860-95-7 5''''-Bromo-4''-octyl-[2,2';5',2'';5'',2''';5''',2'''']quinquethiophene-5-carboxylic acid benzyl ester 
• 204701-16-6 4''-Octyl-[2,2';5',2'';5'',2''';5''',2'''']quinquethiophene-5-carboxylic acid benzyl ester 
• 204701-15-5 5''-Bromo-4''-octyl-[2,2';5',2'']terthiophene-5-carboxylic acid benzyl ester 
• 204701-14-4 4''-Octyl-[2,2';5',2'']terthiophene-5-carboxylic acid benzyl ester 
• 204701-13-3 5'-Bromo-[2,2']bithiophenyl-5-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Structural, spectroscopic, and computational studies of [2,2′-bithiophene]-5-carboxylic acid

The crystal structure of [2,2′-bithiophene]-5-carboxylic acid was obtained from in-situ decarboxylation of [2,2′-bithiophene]-5,5′-dicarboxylic acid during solvothermal treatment. UV-Vis absorption and fluorescence spectroscopies were conducted in solution and solid-state on these two molecules as well as the precursor, 2,2′-bithiophene. These molecules were modeled using DFT level of theory to explain the observed structural features and spectroscopy.

Amide compounds

The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R1is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl group, R2is a hydrogen atom or a lower alkyl

COMPOUNDS USEFUL AS AICARFT INHIBITORS

Compounds of the formula:(where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.

Medicinal thiophene compounds

A method of treating tumor including administering to a subject an effective amount of a compound of the following formula: STR1 wherein m is 1-4; and each of A and B, independently, is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, (CH2)n CHO, (CH2)o COOH, C1-7 alkoxy, C2-7 alkoxyalkyl, C1-7 hydroxyalkyl, CN, NO2, halogen, CH(OR1)2, CO.R1, NR2 R3 or its acid salt, CO.NR2 R3, CHR1 NR2 R3 or its acid salt, CH=NR2, C CR4, CR1 =CR5 R6, CO.CH=CHR7, CH=CHR8, or COOR9 ; in which each of n and o, independently, is 0-4; R1 is C1-4 alkyl or C1-4 acyl; each of R2 and R3, independently, is H, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 is H, C1-4 alkyl, C2-4 alkenyl, COR2, COOR10, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 halogenated alkyl; OR1, or NHR7 ; each of R5 and R6, independently, is H, CHO, COR1, COOH, COOR9, CN, or halogen; R7 is H, C1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R8 is COOR2, CO.CHO, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R9 is H, C1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2-thienyl.

Medicinal thiophene compounds

A method of augmenting the immune system including administering to a subject an effective amount of a compound of the following formula: STR1 wherein m is 1-4; and each of A and B, independently, is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, (CH2)n CHO, (CH2)o COOH, C1-7 alkoxy, C2-7 alkoxyalkyl, C1-7 hydroxyalkyl, CN, NO2, halogen, CH(OR1)2, CO.R1, NR2 R3 or its acid salt, CO.NR2 R3, CHR1 NR2 R3 or its acid salt, CH=NR2, C CR4, CR1 =CR5 R6, CO.CH=CHR7, CH=CHR8, or COOR9 ; in which each of n and o, independently, is 0-4; R1 is C1-4 alkyl or C1-4 acyl; each of R2 and R3, independently, is H, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 is H, C1-4 alkyl, C2-4 alkenyl, COR2, COOR10, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 halogenated alkyl; OR1, or NHR7 ; each of R5 and R6, independently, is H, CHO, COR1, COOH, COOR9, CN, or halogen; R7 is H, C1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R8 is COOR2, CO.CHO, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R9 is H, C1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2-thienyl.

Medicinal thiophene compounds

A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: STR1 wherein m is 1-4; and each of A and B, independently, is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, (CH2)n CHO, (CH2)o COOH, C1-7 alkoxy, C2-7 alkoxyalkyl, C1-7 hydroxyalkyl, CN, NO2, halogen, CH(OR1)2, CO.R1, NR2 R3 or its acid salt, CO.NR2 R3, CHR1 NR2 R3 or its acid salt, CH=NR2, C CR4, CR1 =CR5 R6, CO.CH=CHR7, CH=CHR8, or COOR9 ; in which each of n and o, independently, is 0-4; R1 is C1-4 alkyl or C1-4 acyl; each of R2 and R3, independently is H, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 is H, C1-4 alkyl, C2-4 alkenyl, COR2, COOR10, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 halogenated alkyl; OR1, NHR7 ; each of R5 R6, independently, is H, CHO, COR1, COOH, COOR9, CN, or halogen; R7 is H, C1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R8 is COOR2, CO.CHO, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R9 is H, C1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2 -thienyl.