20600-64-0Relevant academic research and scientific papers
INHIBITORS OF MUTANT FORMS OF EGFR
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Page/Page column 37-38, (2021/07/02)
The present disclosure provides a compound represented by structural formula (I) : or a pharmaceutically acceptable salt thereof useful for treating a cancer.
Synthesis of α-fluorinated-α,α-difunctionalized sulfides and sulfones
Jouen,Lasne,Pommelet
, p. 2413 - 2416 (2007/10/03)
The highly functionalized organofluorine compounds 3a-c were prepared from the activated dichlorinated sulfides 2a-c by displacement of a chlorine atom using nucleophilic fluorination agents such as dihydrogenfluoride polymer-supported. Fluorination of sulfoxides 5a-c with diethylaminosulfur trifluoride gives monofluoro sulfides 6a-c, subsequently transformed into α-chloro-α-fluoro sulfides 3a-c and sulfones 7a-c.
Sulfonyl Esters. V. A Preparation of Dichloromethyl Sulfones
Langler, Richard Francis,Steeves, Jennifer Lea
, p. 1641 - 1646 (2007/10/02)
α-Sulfonyl methyl esters have been chlorinated in the presence of base.Chlorination proceeds with accompanying demethoxycarbonylation to furnish dichloromethyl sulfones in good yields.
