20601-92-7

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 79-04-9 chloroacetyl chloride 
• 99-40-1 2-chloro-3',4'-dihydroxyacetophenone 
• 77-78-1 dimethyl sulfate 
• 120-80-9 benzene-1,2-diol 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 64834-75-9 1,1,1-trichloro-2-(3,4-dimethoxyphenyl)-2-ethanol 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 93-07-2 Veratric acid 
• 52196-76-6 2-diazo-1-(3,4-dimethoxyphenyl)ethan-1-one 

Downstream Products

• 109646-62-0 1-(3,4-dimethoxy-phenacyl)-3-hydroxy-pyridinium; chloride 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 117340-84-8 (+)-2-chloro-1-(3,4-dimethoxyphenyl)ethyl acetate 
• 117465-38-0 (R)-2-chloro-1-(3,4-dimethoxyphenyl)ethanol 
• 1544696-11-8 C₁₇H₁₈N₂O₃ 
• 1544696-10-7 C₁₇H₁₈N₂O₃ 
• 1176492-88-8 C₁₆H₁₈ClNO₃ 
• 1544695-86-4 C₁₆H₂₇IO₃Si 
• 1177242-57-7 C₁₆H₁₈ClNO₃ 
• 1175793-40-4 C₁₆H₁₉NO₃ 
• 1544695-81-9 C₁₈H₁₈N₂O₃ 
• 1544695-80-8 C₁₈H₁₈N₂O₃ 
• 61693-05-8 (R)-(-)-2-amino-1-(3,4-dimethoxyphenyl)ethanol 
• 1544695-79-5 C₁₉H₁₉NO₃ 

Relevant academic research and scientific papers

Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

Iridium-catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram-scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f-amphox catalyst with 99% yield and >99% ee. (Figure presented.).

X-ray crystallography and computational docking for the detection and development of protein-ligand interactions

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterised by the selective dysfunction and death of the upper and lower motor neurons. Median survival rates are between 3 and 5 years after diagnosis. Mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) have been linked to a subset of familial forms of ALS (fALS). Herein, we describe a fragment- based drug discovery (FBDD) approach for the investigation of small molecule binding sites in SOD1. X-ray crystallography has been used as the primary screening method and has been shown to directly detect protein-ligand interactions which cannot be unambiguously identified using other biophysical methods. The structural requirements for effective binding at Trp32 are detailed for a series of quinazoline-containing compounds. The investigation of an additional site that binds a range of catecholamines and the use of computational modelling to assist fragment evolution is discussed. This study also highlights the importance of ligand solubility for successful Xray crystallographic campaigns in lead compound design.

Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols

(Chemical Equation Presented) Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.

Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

A series of CCK-B/gastrin receptor antagonists, 2,4-dioxo-1,5-benzodiazepine derivatives with a plane of symmetry, were designed, synthesized, and evaluated for antagonistic activity. Structure-activity relationship studies revealed that carbonylmethyl groups at both N-1 and N-5 positions and hydrophilic groups, such as the carboxyl group on the benzene ring attached to the ureido group at the C-3 position, brought about potent affinity and subtype selectivity for CCK-B/gastrin receptors. Several compounds showed excellent in vivo inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats.