206555-98-8Relevant articles and documents
The tetrahydropyranyl-protected mandelic acid: A novel versatile chiral derivatising agent
Parve, Omar,Aidnik, Madis,Lille, Uelo,Martin, Ivar,Vallikivi, Imre,Vares, Lauri,Pehk, Tonis
, p. 885 - 896 (2007/10/03)
A simple synthesis of (2R)-2-phenyl-2-[(2S)-tetrahydro-2- pyranyloxy]ethanoic acid, a versatile chiral derivatising agent (CDA), is proposed. The derivatisation of secondary alcohols aimed at the absolute configurational assignment, determination of enantiomeric purity as well as semipreparative resolution is described.